Results 31 to 40 of about 44,172 (244)

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

To Resurface or Not to Resurface the Patella in Total Knee Arthroplasty, That Is the Question: A Meta-Analysis of Randomized Controlled Trials

Medicina, 2022
Background and Objetives: Currently, total knee arthroplasty is one of the most common surgeries, increasing with the increase in life expectancy. Whether or not to replace the patella has been a subject of debate over the years, remaining in controversy
Alberto Delgado-González, Juan José Morales-Viaji, Jose Gregorio Arteaga-Hernández, Ángela Larrosa-Arranz, Guillerno Criado-Albillos, Adoración del Pilar Martin-Rodríguez, Maha Jahouh, Josefa González-Santos, Leticia Mendieta Díaz, Carla Collazo Riobo, Sara Calvo Simal, Jerónimo Javier González-Bernal   +11 more
doaj   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

On the role of the J-E constitutive relationship in applied geoelectromagnetism

Annals of Geophysics, 2003
In current applications of the Induced Polarization (IP) method, the Debye and Cole-Cole models are used to study relaxation and dispersion properties of rocks, though it is believed that this type of modelisation is confused and vague, because
D. Patella
doaj   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Osteonecrosis of bipartite patella following total knee arthroplasty without lateral release

Acta Orthopaedica et Traumatologica Turcica, 2019
We present a case of osteonecrosis of bipartite patella occurring after total knee arthroplasty using medial parapatellar approach without lateral retinacular release in osteoarthritic knee of a 66 year-old-male.
Jung Ho Noh, Young Hak Roh
doaj   +1 more source

Atlas-Based Segmentation in Extraction of Knee Joint Bone Structures from CT and MR

Sensors, 2022
The main goal of the approach proposed in this study, which is dedicated to the extraction of bone structures of the knee joint (femoral head, tibia, and patella), was to show a fully automated method of extracting these structures based on atlas ...
Piotr Zarychta
doaj   +1 more source

Distal femoral morphology as a risk factor for osteoarthritis

The Anatomical Record, EarlyView.
Abstract Osteoarthritis (OA) is a leading cause of disability affecting millions of adults in the United States, commonly resulting in the need for total knee arthroplasty (TKA) to restore mobility and quality of life. This study investigates potential differences in baseline distal femoral shape between individuals who received TKA due to OA and a ...
Haley Horbaly
wiley   +1 more source

Novel application of gamification to support undergraduate anatomy: Student perceptions and performance

Anatomical Sciences Education, EarlyView.
Abstract Anatomy is a foundational component of various medical and paramedical disciplines. Existing research has suggested that games or game elements can improve student interest in musculoskeletal (MSK) anatomy. This project builds on previous gamification and serious game work and incorporates new anatomy‐based games into undergraduate anatomy ...
Emmeline Berger, Jacqueline Carnegie, Christopher J. Ramnanan   +2 more
wiley   +1 more source

Lower Limb Biomechanical Variables Are Indicators of the Pattern of Presentation of Patella Tendinopathy in Elite African Basketball and Volleyball Players [PDF]

Revista Brasileira de Ortopedia, 2019
Objective The present study determined the pattern of presentation and severity of patellar tendinopathy (PT) and its relationship with selected biomechanical variables in elite athletes.
Ayoola Aiyegbusi, Bidemi Tella, Chukwuebuka Okeke   +2 more
doaj   +3 more sources