Results 141 to 150 of about 23,442,365 (336)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

University Patenting in Wales, Scotland and Northern Ireland: a Comparative Analysis [PDF]

, 2008
Andrew V. Beale, David Blackaby, Lynn Mainwaring   +2 more
openalex   +1 more source

Patent analysis of a medicinal plant as a source of natural products and drugs: <em>Rosmarinus officinalis</em> (Rosemary)

, 2021
Ahmed Fatimi
openalex   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Leveraging patent analysis to measure relatedness between technology domains: an application on offshore wind energy

Environmental Research Letters
As the global energy sector transitions towards a cleaner and more sustainable future, observational evidence suggests that many new energy technologies share a close relationship with well-established technologies.
Yiwen Wang, Erin Baker, Anna Goldstein
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Exploring the nanobody patent landscape: a focus on BCMA sequences and structural analysis

mAbs
Nanobodies (Nbs) are antigen-binding fragments derived from unique heavy-chain-only antibodies. In recent years, the development of Nbs has progressed rapidly due to their therapeutic potential.
Jiaqi Xu, Yan Wang, Ni Yuan, Guang Hu, Yuanjia Hu   +4 more
doaj   +1 more source

NPEs’ patent acquisitions : empirical analysis of patent data

, 2018
nhhmas
Nilsen, Magne, Paudel, Prakash Raj
openaire   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Clinical Efficacy of Chinese patent medicines combined with standard drug treatment for treatment of lupus nephritis in Adults: A Multiple-Treatment Meta-Analysis [PDF]

Liquan yuan, Q. Zhang, Aiguo Lu, Sini Li, ciyan Peng, Mei‐Chin Wen, Jing Chen   +6 more
openalex   +1 more source