Results 91 to 100 of about 19,095 (287)
The Transformative Patent Landscape in Saudi Arabia Since the Saudi Vision 2030 Announcement
PublicationsThis study analyzes the patent landscape of Saudi Arabia from the announcement of Saudi Vision 2030 in late April 2016 to September 2024, utilizing the Patsnap database to evaluate patent grants across various organizations. The findings reveal a gradual
Mohammed Abdulfasi
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The CRISPR patent landscape: a South African perspective. [PDF]
, 2020 Masters Degree. University of KwaZulu-Natal, Durban.The patent rights to CRISPR technology in different jurisdictions have been fought over tirelessly by both public and private actors.
Naidoo, Meshandren.
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Exploring New Frontiers in Patent Fossa Ovalis Closure
Journal of Interventional CardiologyPercutaneous closure of patent fossa ovalis in patients with paradoxical embolism has gradually emerged as an increasingly compelling alternative to prolonged medical therapy.
Gregory A. Sgueglia, Achille Gaspardone
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The CRISPR Patent Landscape: Past, Present, and Future [PDF]
, 2018 The development of CRISPR depends, in part, on the patents—past, present, and future—covering it. As for the past, the origins of the CRISPR patent landscape predate its use as a gene editing technology.
Jacob S. Sherkow, Sherkow, Jacob S.
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Patent landscape analysis: How to find information on hydrogen peroxide industrial syntheses [PDF]
The objective of this presentation is to provide an overview of the methodology employed in patent landscape analyses (PLA), with a particular focus on the patented processes used to produce hydrogen peroxide.
Barbieri, Massimo
core +1 more source