Results 111 to 120 of about 19,095 (287)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Patent Landscape Report ::Production of Titanium and Titanium Dioxide from Ilmenite and Related Applications Datasets. [PDF]

This report provides a landscape of the patent activity on the process of extracting titanium dioxide or titanium metal from ilmenite ore. In addition, a section on the industrial applications of titanium dioxide and titanium metal focuses on selected ...

core   +1 more source

Estimation of Multispeed Hydromechanical Transmissions Development Trends with the Use of Patent Landscapes and Computational Analysis

Механика машин, механизмов и материалов, 2018
This paper discusses the use of patent landscapes as a tool for collecting information and identifying development trends of multispeed hydromechanical transmissions and presents a method of collecting data for patent maps drafting. The main attention is
Evgeni V. Kuznetsov, Vladimir B. Algin
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Patenting Behavior of Academic Founders [PDF]

This study explores why academic entrepreneurs patent their inventions before and after creating a firm. Drawing on start-up data combined with patent data, we specifically examine the impact of five, relatively under-researched factors (scientific field,
Walter, Sascha G., Walter, Achim, Schmidt, Arne   +2 more
core  

Temporal Trends in the United States Patent Landscape: Innovation in Cardiology Across Industry and Academia. [PDF]

Cardiol Res, 2023
Wadhwa RR, McElderry BM, Yu J, Kapadia SR, Gillinov AM, Svensson LG, Desai MY.   +6 more
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Navigating the molecular diagnostic patent landscape [PDF]

, 2008
Background: The molecular diagnostic patent landscape mostly comprises patents claiming rights over genes and other research tools. Many such patents have been granted and many more await examination.
Dianne Nicol (14745490)
core   +2 more sources

Organic Agriculture: Giving Low-Tech a Chance? An overview of the patent landscape: Tecnología artesanal? Revisión del panorama de patentamiento

AD-minister
This research overview the patent landscape of the inputs approved for certified organic agriculture. For this, it explains the tensions in regards to private voluntary standards addressed in certain trade-related forums.
Luis Gil Abinader
doaj