Results 101 to 110 of about 1,387,926 (283)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Temporal Trends in the United States Patent Landscape: Innovation in Cardiology Across Industry and Academia. [PDF]
Cardiol Res, 2023 Wadhwa RR +6 more
europepmc +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
TB vaccine development: monitoring international patent filings to anticipate access challenges
Frontiers in Public HealthIntroductionEvery year, an estimated 10 million new cases of tuberculosis (TB) are diagnosed, and 1.6 million deaths occur worldwide due to this disease.
María Florencia Pignataro +6 more
doaj +1 more source
The worldwide patent landscape of dental implant technology. [PDF]
Biomater Res, 2022 Kim WJ, Cho YD, Ku Y, Ryoo HM.
europepmc +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
AD-ministerThis research overview the patent landscape of the inputs approved for certified organic agriculture. For this, it explains the tensions in regards to private voluntary standards addressed in certain trade-related forums.
Luis Gil Abinader
doaj
Applied System InnovationAs the patent landscape continues to grow, so does the complexity of retrieving relevant “prior art”, “background art”, or “state of the art” from an expanding pool of publicly available patent data, a critical step in establishing novelty.
Amna Ali +3 more
doaj +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source