Results 51 to 60 of about 40,373 (162)

Characterizing circadian rest–activity rhythm patterns across Alzheimer's disease continuum in Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Sleep and circadian rest–activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR patterns across the DS‐associated AD continuum remain uncharacterized. METHODS We analyzed 7‐day wrist actigraphy in 140 adults
Sandra Giménez, Lídia Vaqué‐Alcázar, Susana Clos, Bessy Benejam, Maria Carmona‐Iragui, Lucía Maure‐Blesa, Laura Videla, Nuole Zhu, Miren Altuna, Javier Arranz, Isabel Barroeta, Íñigo Rodríguez‐Baz, Alexandre Bejanin, Ana Bueno, Susana Fernandez, Laura del Hoyo Soriano, Lucia Pertierra, Daniel Alcolea, Bruce Miller, Lea T. Grinberg, Joaquin Ruiz, Christos Panagiotis Lisgaras, Hau‐Tieng Wu, Alberto Lleó, Ricardo S. Osorio, Esther M. Blessing, Juan Fortea   +26 more
wiley   +1 more source

LAS PATENTES FARMACÉUTICAS Y EL COMERCIO DEL MEDICAMENTO [PDF]

, 2016
El objetivo de este estudio es realizar un análisis de cómo un reparto insostenible de recursos dificulta el acceso a medicamentos a la sociedad en países en vías de desarrollo y subdesarrollados.
MORLA GONZÁLEZ, MARINA
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Propiedad intelectual y patentes sobre usos medicinales en conocimientos tradicionales

Investigación Agraria, 2018
En este trabajo se analiza el conocimiento tradicional sobre las supuestas propiedades medicinales de plantas y sus usos, como parte de los bienes comunes, que tiene la protección del derecho interno y del derecho internacional. Se consideran los usos de
Ramón Fogel
doaj   +1 more source

Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome–associated Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION This study investigates the evolution with disease progression and pathological correlates of peak width of skeletonized mean diffusivity (PSMD), a sensitive diffusion magnetic resonance imaging (MRI) marker of microvascular white matter (WM) injury, in sporadic Alzheimer's disease (sAD) and Down syndrome (DS)–associated AD (DSAD).
Alejandra O. Morcillo‐Nieto, Maria Franquesa‐Mullerat, Sara E. Zsadanyi, José Enrique Arriola‐Infante, Lídia Vaqué‐Alcázar, Mateus Rozalem‐Aranha, José Allende Parra, Zili Zhao, Javier Arranz, Íñigo Rodríguez‐Baz, Lucia Maure‐Blesa, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Lucia Pertierra, Sandra Giménez, Miguel Santos‐Santos, Oriol Dols‐Icardo, Ignacio Illán‐Gala, Daniel Alcolea, Olivia Belbin, Alberto Lleó, María Carmona‐Iragui, Juan Fortea, Alexandre Bejanin   +27 more
wiley   +1 more source

Mapping the Technological and Pharmacological Landscape of Casearia sylvestris: An Evidence‐Based Prospection for Wound Healing and Pain Management

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Technological prospection of Casearia sylvestris for wound healing reveals limited patent and scientific production, concentrated on topical formulations and associated analgesic and anti‐inflammatory properties. Key innovation gaps persist, including insufficient chemical and biological standardization, lack of clinical evidence, and restricted ...
Luiza Gonçalves Soutier, Yasmim Parisotto de Souza Silva, Carla Suelen Gurski, Jaqueline Carneiro, Jéssica Brandão Reolon, Roberto Pontarolo, Marcel Henrique Marcondes Sari, Gabriel Blum Vestena, Weber Cláudio Francisco Nunes da Silva, Juliana Sartori Bonini, Luana Mota Ferreira   +10 more
wiley   +1 more source

Monovalent mannose‐glycoconjugates of sulforaphane reprogram human dendritic cells via NFATc1 to induce immune tolerance under inflammatory conditions

British Journal of Pharmacology, Volume 183, Issue 9, Page 1993-2008, May 2026.
Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez, Camila Leiva‐Castro, Ana M. Múnera‐Rodríguez, Macarena Martínez‐Bailén, Ana T. Carmona, Soledad López‐Enríquez, Francisca Palomares   +6 more
wiley   +1 more source

La traducción de los folletos de patentes farmacéuticas: análisis comparativo en tres idiomas [PDF]

, 2017
Este trabajo se basa en el concepto de género textual y, en concreto, en el folleto de patentes farmacéuticas. El marco teórico presenta la situación de las patentes, haciendo hincapié en las patentes farmacéuticas (y la legislación en la que se enmarcan)
Jato Rodríguez, Mikel
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La financiarización de las grandes empresas farmacéuticas

Revista Internacional de Sociología, 2020
En este artículo, empleamos un marco Vebleniano para analizar tres dimensiones de la financiarización corporativa: la expansión del balance, la creciente importancia de los activos intangibles y los crecientes niveles de pagos financieros.
Tobias J. Klinge, Rodrigo Fernandez, Manuel B. Aalbers   +2 more
doaj   +1 more source

A Comprehensive Evaluation of Patient Satisfaction and Clinical Outcomes in Poly‐L‐Lactic Acid Treatments—A Randomized, Interventional, and Comparative Clinical Study

Journal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background Poly‐L‐lactic acid (PLLA) is widely used in aesthetic medicine due to its bio‐stimulatory properties. However, limited research has compared different PLLA formulations. Aim To evaluate the impact of PLLA formulation and injection depth (subcutaneous vs. supraperiosteal) using objective and subjective assessments.
Victor R. M. Munoz‐Lora, Danielle Dias, Fernanda Bezerra, Ana C. N. Carnevali, Rud Varela, Andrea D. Tedesco, Pietra Roschel, Gabriela Giro, Patrícia Pauletto, Victor Rogerio, Marcelo Germani   +10 more
wiley   +1 more source

A inovação nas incubadoras tecnológicas :: uma análise sob a ótica das patentes / [PDF]

, 1999
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico.Resultado de uma pesquisa realizada com 73 empresas residentes em 9 incubadoras tecnológicas no Brasil, a proposta deste estudo é analisar as inovações desenvolvidas ...
Prado, Evandro José da Silva
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