Results 101 to 110 of about 147,683 (344)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Special Libraries, June 1924 [PDF]

, 1921
Volume 15, Issue 6https://scholarworks.sjsu.edu/sla_sl_1924/1005/thumbnail ...
Special Libraries Association
core   +8 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

One-Class Support Vector Machine and LDA Topic Model Integration—Evidence for AI Patents

, 2021
Anton Thielmann, Christoph Weisser, Astrid Krenz   +2 more
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Special Libraries, April 1940 [PDF]

, 1939
Volume 31, Issue 4https://scholarworks.sjsu.edu/sla_sl_1940/1003/thumbnail ...
Special Libraries Association
core   +4 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Discovering patterns and trends in customer service technologies patents using large language model

Heliyon
The definition of service has evolved from a focus on material value in manufacturing before the 2000s to a customer-centric value based on the significant growth of the service industry.
Chaeyeon Kim, Juyong Lee
doaj   +1 more source

Money, the market, and the military origins of the American System [PDF]

Economia e Sociedade
This article discusses the development of mass production technology in the United States. Like spaceflight and the computer, this technology grew out of a state-led effort to promote technical progress in weapons and defense production, giving rise to ...
Nicholas Miller Trebat
doaj   +1 more source

The determinants of scientific research agenda: Why do academic inventors choose to perform patentable versus non-patentable research? [PDF]

This paper explores the determinants of scientific research agenda. By using an original dataset that includes extensive information about 269 French academic inventors, we analyze why scientists choose to perform patentable versus non-patentable ...
Hussler Caroline, Pénin Julien
core