Results 31 to 40 of about 2,070,985 (262)

Performance of an ultra-sensitive Plasmodium falciparum HRP2-based rapid diagnostic test with recombinant HRP2, culture parasites, and archived whole blood samples

Malaria Journal, 2018
Background As malaria endemic countries shift from control to elimination, the proportion of low density Plasmodium falciparum infections increases.
Smita Das, Roger B. Peck, Rebecca Barney, Ihn Kyung Jang, Maria Kahn, Meilin Zhu, Gonzalo J. Domingo   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Path-analytic models’ fit.

, 2018
Path-analytic models’ fit.
Taylor Kohut (4034540), Aleksandar Štulhofer (5620931)   +1 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Formulation and preclinical studies with a trivalent rotavirus P2-VP8 subunit vaccine

Human Vaccines & Immunotherapeutics, 2020
More effective rotavirus vaccines are essential for preventing extensive diarrheal morbidity and mortality in children under five years of age in low-resource regions.
Kyle Lakatos, David McAdams, Jessica A. White, Dexiang Chen   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Comparative analysis of the use of Community Health Workers while deploying the Attractive Targeted Sugar Bait (ATSB) for malaria control in Western Province, Zambia

Malaria Journal
Background Community Health Workers (CHWs) play a crucial role in malaria control efforts, yet their contributions to large-scale field trials remain understudied.
Frank Ndalama, David Mulenga, Annie Arnzen, Situmbeko Akalalambili, Titus Tobolo, Chuma Maluma, Chama Chishya, Kochelani Saili, Ruth A. Ashton, John Miller, Kafula Silumbe, Javan Chanda, Busiku Hamainza, Megan Littrell, Erica Orange   +14 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Dynamic Path Planning for a 7-DOF Robot Arm [PDF]

, 2006
Klanke S, Lebedev DV, Haschke R, Steil JJ, Ritter H. Dynamic Path Planning for a 7-DOF Robot Arm. In: Int. Conf. Intelligent Robots and Systems.
Stefan Klanke, Jochen Steil, Ritter, Helge ; https://orcid.org/, Haschke, Robert ; https://orcid.org/, Steil, Jochen J., Robert Haschke, Helge Ritter, Lebedev, Dmitry V., Klanke, Stefan, Dmitry Lebedev   +9 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source