Results 41 to 50 of about 2,070,985 (262)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Supporting primary health care led preventive screening through community-embedded health access points in Ukraine

Frontiers in Public Health
IntroductionEnsuring timely, affordable access to preventive screening and early detection of noncommunicable diseases (NCDs) is essential for resilient primary health care (PHC), yet coverage remains uneven in rural and hard-to-reach communities in ...
Halyna Darahan, Roman Rodyna, Myroslava Germanovych, Aleksey Bogdanov, Natalia Zaika, Kateryna Gamazina, Eveline Klinkenberg, Gunta Dravniece   +7 more
doaj   +1 more source

Current and cumulative malaria infections in a setting embarking on elimination: Amhara, Ethiopia

Malaria Journal, 2017
Background Since 2005, Ethiopia has aggressively scaled up malaria prevention and case management. As a result, the number of malaria cases and deaths has significantly declined.
Woyneshet G. Yalew, Sampa Pal, Pooja Bansil, Rebecca Dabbs, Kevin Tetteh, Caterina Guinovart, Michael Kalnoky, Belendia A. Serda, Berhane H. Tesfay, Belay B. Beyene, Catherine Seneviratne, Megan Littrell, Lindsay Yokobe, Gregory S. Noland, Gonzalo J. Domingo, Asefaw Getachew, Chris Drakeley, Richard W. Steketee   +17 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Experiences from Ukraine in expanding TB infection diagnosis and treatment, including for drug-resistant TB

IJTLD Open
BACKGROUND: Ukraine faces intersecting epidemics of HIV and drug-resistant TB (DR-TB), with high risk of progression from TB infection to active disease.
V. Shukatka, L. Skoklyuk, M. Germanovych, A. Bogdanov, T. Ivanenko, N. Zherebko, E. Klinkenberg, G. Dravniece   +7 more
doaj   +1 more source

sud03r/min-color-path v1.0

, 2019
<p>code and datasets for min-color path</p> <p><a href="https://github.com/sud03r/min-color-path">https://github.com/sud03r/min-color-path</a></p ...
Neeraj Kumar
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Performance and usability evaluation of three LDH-based malaria rapid diagnostic tests in Kédougou, Senegal

Parasites & Vectors
Background The emergence of Plasmodium falciparum (Pf) parasites with deleted histidine-rich protein 2 and 3 (hrp2/hrp3) genes threatens the performance of HRP2-based malaria rapid diagnostic tests (RDTs).
Babacar Souleymane Sambe, Stephanie Zobrist, William Sheahan, Divya Soni, Aissatou Diagne, Ibrahima Sarr, Arona Sabene Diatta, Serigne Ousmane Mbacke Diaw, Allison Golden, Hannah Slater, Ihn Kyung Jang, Nerie Roa, Sampa Pal, Fatoumata Diene Sarr, Joseph Faye, Inès Vigan-Womas, Yakou Dieye, Moustapha Cisse, Gonzalo J. Domingo, Makhtar Niang   +19 more
doaj   +1 more source

Robust three-dimensional best-path phase-unwrapping algorithm that avoids singularity loops [PDF]

, 2009
In this paper we propose a novel hybrid three-dimensional phase-unwrapping algorithm, which we refer to here as the three-dimensional best-path avoiding singularity loops (3DBPASL) algorithm.
Burton, David, Arevalillo-Herráez, Miguel, Gdeisat, Munther, Abdul-Rahman, Hussein S., Qudeisat, Mohammed, Lilley, Francis, Sheltraw, Daniel, Lalor, Michael, Moore, Christopher   +8 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source