Results 41 to 50 of about 925,289 (268)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Frontiers in Public HealthIntroductionEnsuring timely, affordable access to preventive screening and early detection of noncommunicable diseases (NCDs) is essential for resilient primary health care (PHC), yet coverage remains uneven in rural and hard-to-reach communities in ...
Halyna Darahan +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
IJTLD OpenBACKGROUND: Ukraine faces intersecting epidemics of HIV and drug-resistant TB (DR-TB), with high risk of progression from TB infection to active disease.
V. Shukatka +7 more
doaj +1 more source
Real Analysis Exchange, 2004 If \(E\) is a system of paths, then the function \(f\) is \(E\)-continuous at \(x\) if there exists a path \(A\in E(x)\) such that \(f\) restricted to \(A\) is continuous at \(x\). A function \(f\) is called \(E\)-continuous if it is \(E\)-continuous at each \(x\).
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Parasites & VectorsBackground The emergence of Plasmodium falciparum (Pf) parasites with deleted histidine-rich protein 2 and 3 (hrp2/hrp3) genes threatens the performance of HRP2-based malaria rapid diagnostic tests (RDTs).
Babacar Souleymane Sambe +19 more
doaj +1 more source
Current and cumulative malaria infections in a setting embarking on elimination: Amhara, Ethiopia
Malaria Journal, 2017 Background Since 2005, Ethiopia has aggressively scaled up malaria prevention and case management. As a result, the number of malaria cases and deaths has significantly declined.
Woyneshet G. Yalew +17 more
doaj +1 more source