Results 61 to 70 of about 6,144,048 (289)

Formulation and preclinical studies with a trivalent rotavirus P2-VP8 subunit vaccine

Human Vaccines & Immunotherapeutics, 2020
More effective rotavirus vaccines are essential for preventing extensive diarrheal morbidity and mortality in children under five years of age in low-resource regions.
Kyle Lakatos, David McAdams, Jessica A. White, Dexiang Chen   +3 more
doaj   +1 more source

A Template for Implementing Fast Lock-free Trees Using HTM

, 2017
Algorithms that use hardware transactional memory (HTM) must provide a software-only fallback path to guarantee progress. The design of the fallback path can have a profound impact on performance.
Brown T., Dice D., He M., Lev Y., Nguyen A. T.   +4 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Directed path graphs [PDF]

, 1996
The concept of a line digraph is generalized to that of a directed path graph. The directed path graph $\overrightarrow P_k(D)$ of a digraph D is obtained by representing the directed paths on k vertices of D by vertices.
Broersma, Hajo, Li, Xueliang
core   +1 more source

On Path Continuity

Real Analysis Exchange, 2004
If \(E\) is a system of paths, then the function \(f\) is \(E\)-continuous at \(x\) if there exists a path \(A\in E(x)\) such that \(f\) restricted to \(A\) is continuous at \(x\). A function \(f\) is called \(E\)-continuous if it is \(E\)-continuous at each \(x\).
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Supporting primary health care led preventive screening through community-embedded health access points in Ukraine

Frontiers in Public Health
IntroductionEnsuring timely, affordable access to preventive screening and early detection of noncommunicable diseases (NCDs) is essential for resilient primary health care (PHC), yet coverage remains uneven in rural and hard-to-reach communities in ...
Halyna Darahan, Roman Rodyna, Myroslava Germanovych, Aleksey Bogdanov, Natalia Zaika, Kateryna Gamazina, Eveline Klinkenberg, Gunta Dravniece   +7 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source