Results 71 to 80 of about 6,144,048 (289)
IJTLD OpenBACKGROUND: Ukraine faces intersecting epidemics of HIV and drug-resistant TB (DR-TB), with high risk of progression from TB infection to active disease.
V. Shukatka +7 more
doaj +1 more source
Clinical and Translational Science, 2021 Interest in drug development for rare diseases has expanded dramatically since the Orphan Drug Act was passed in 1983, with 40% of new drug approvals in 2019 targeting orphan indications. However, limited quantitative understanding of natural history and
Ariana P. Mullin +10 more
doaj +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Parasites & VectorsBackground The emergence of Plasmodium falciparum (Pf) parasites with deleted histidine-rich protein 2 and 3 (hrp2/hrp3) genes threatens the performance of HRP2-based malaria rapid diagnostic tests (RDTs).
Babacar Souleymane Sambe +19 more
doaj +1 more source
Current and cumulative malaria infections in a setting embarking on elimination: Amhara, Ethiopia
Malaria Journal, 2017 Background Since 2005, Ethiopia has aggressively scaled up malaria prevention and case management. As a result, the number of malaria cases and deaths has significantly declined.
Woyneshet G. Yalew +17 more
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Corrections to the Boltzmann mean free path in disordered systems with finite size scatterers
, 2001 The mean free path is an essential characteristic length in disordered systems. In microscopic calculations, it is usually approximated by the classical value of the elastic mean free path.
Correia S +10 more
core +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
A new tunneling path for reactions such as H+H_2→H_2+H [PDF]
, 1977 The standard tunneling path in transition state theory for reactions such as H+H_2→H_2+H has been the so‐called reaction path, namely the path of steepest ascent to the saddle point.
Coltrin, Michael E., Marcus, R. A.
core
Elaborating Transition Interface Sampling Methods
, 2004 We review two recently developed efficient methods for calculating rate constants of processes dominated by rare events in high-dimensional complex systems.
Allen +51 more
core +2 more sources