Results 61 to 70 of about 4,045,344 (304)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Robot Path Generation Method for a Welding System Based on Pseudo Stereo Visual Servo Control

EURASIP Journal on Advances in Signal Processing, 2005
A path generation method for robot-based welding systems is proposed. The method that is a modification of the method "teaching by showing" is supported by the recently developed pseudo stereovision system (PSVS).
Tarchanidis Kostas N, Pachidis Theodore P, Lygouras John N, Tsalides Philippos G   +3 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Sample Path Generation of the Stochastic Volatility CGMY Process and Its Application to Path-Dependent Option Pricing

, 2021
This paper proposes the sample path generation method for the stochastic volatility version of the CGMY process. We present the Monte-Carlo method for European and American option pricing with the sample path generation and calibrate model parameters to ...
Kim, Young Shin, Young Shin Kim
core   +1 more source

New Variable-Structure Floating Linkage Mechanism

Engineering Proceedings
A new three-degree-of-freedom (3-DOF) variable-structure floating linkage mechanism is presented in this article. The proposed mechanism consists of six links, five revolute joints, and one rolling or sliding joint.
Ren-Chung Soong
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Analytical Synthesis of Planar Four-Bar Linkages for Coupler-Curve Path Generation Through Precision Points

Engineered Science
This paper was performed using geometry and interactive motion (GIM) software, a learning and research software designed to facilitate the kinematic analysis and synthesis of planar mechanisms.
Zhastalap Abilkaiyr, Algazy Zhauyt, Kuanysh Alipbayev, Yerbol Kaliyev, Nazgul Kaliyeva, Nurgul Kurmangaliyeva   +5 more
doaj   +1 more source

Structure and tensile properties evaluation of samples produced by Fused Deposition Modeling

Open Engineering, 2016
This paper presents the result of a study evaluating the influence of alternative path generation strategy on structure and some mechanical properties of parts produced by Fused Deposition Modeling (FDM) technology.
Gajdoš Ivan, Slota Ján, Spišák Emil, Jachowicz Tomasz, Tor-Swiatek Aneta   +4 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source