Results 201 to 210 of about 5,803 (234)
Translocation of a Gut Pathobiont Drives Autoimmunity in Mice and Humans [PDF]
Science, 2018 Bacterial involvement in autoimmunity The composition of the commensal microbiota is known to influence autoimmune disease development and persistence. Manfredo Vieira et al. identified a gut microbe, Enterococcus gallinarum , that ...
Carina Dehner +2 more
exaly +4 more sources
A Gut Pathobiont Synergizes With the Microbiota to Instigate Inflammatory Disease Marked by Immunoreactivity Against Other Symbionts but Not Itself [PDF]
Scientific Reports, 2017 Inflammatory bowel diseases (IBD) are likely driven by aberrant immune responses directed against the resident microbiota. Although IBD is commonly associated with a dysbiotic microbiota enriched in putative pathobionts, the etiological agents of IBD ...
Jesse M Hostetter, João C Gomes-Neto
exaly +3 more sources
Label or Concept – What Is a Pathobiont? [PDF]
Trends in Microbiology, 2020 An increasing number of microorganisms are classified as 'pathobionts' (i.e., organisms that can cause harm under certain circumstances) but there exist no universally used criteria for this definition. In particular, the term is often used for categorizing disease-associated taxa without proof of 'causality'.
Bärbel Stecher, Lara Jochum
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Lethal Inflammasome Activation by a Multidrug-Resistant Pathobiont Upon Antibiotic Disruption of the Microbiota [PDF]
Nature Medicine, 2012 The maintenance of a normal intestinal microbiota is associated with gut integrity and healthy immune responses. In this issue, Janelle Ayres and her colleagues report that disruption of the gut microbiome with antibiotics, coupled with gut injury, leads
Janelle Ayres +2 more
exaly +2 more sources
Evolving concepts of host–pathobiont interactions in autoimmunity
Current Opinion in Immunology, 2023Autoimmune diseases are complex, multifactorial diseases with a polygenic trait and diverse environmental factors that contribute to triggering and exacerbating each disorder. The human microbiome is increasingly implicated in the multistep pathogenesis of autoimmune diseases. We summarize here the latest developments in the field of how the microbiota
Márcia S, Pereira, Martin A, Kriegel
openaire +2 more sources
Gut pathobionts as triggers for liver diseases
Nature Microbiology, 2019Klebsiella pneumoniae isolated from patients with primary sclerosing cholangitis was found to cause intestinal barrier dysfunction resulting in T-helper-17-cell-mediated hepatobiliary injury, providing evidence for specific gut-derived, pore-forming pathogens as triggers for immune-mediated liver disease.
Peter, Fickert, Hanns-Ulrich, Marschall
openaire +2 more sources