Results 221 to 230 of about 4,917 (252)
Scientific Reports, 2017 Inflammatory bowel diseases (IBD) are likely driven by aberrant immune responses directed against the resident microbiota. Although IBD is commonly associated with a dysbiotic microbiota enriched in putative pathobionts, the etiological agents of IBD ...
João CARLOS Gomes-Neto +2 more
exaly +4 more sources
Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota [PDF]
Nature Medicine, 2012 The maintenance of a normal intestinal microbiota is associated with gut integrity and healthy immune responses. In this issue, Janelle Ayres and her colleagues report that disruption of the gut microbiome with antibiotics, coupled with gut injury, leads
Janelle S Ayres +2 more
exaly +2 more sources
Draft Genome Sequence of Lactobacillus brevis Strain EW, a Drosophila Gut Pathobiont
Genome Announcements, 2013 Lactobacillus brevis strain EW, a gut pathobiont, was isolated from the fruit flyDrosophila melanogaster. Here, we report the draft genome sequence of L.
Eun-Kyoung Kim +2 more
exaly +1 more source
Pathogens, 2019 Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium that is part of the oral microbiota. The aggregative nature of this pathogen or pathobiont is crucial to its involvement in human disease.
Niels Nørskov-Lauritsen +2 more
exaly +2 more sources
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Evolving concepts of host–pathobiont interactions in autoimmunity
Current Opinion in Immunology, 2023Autoimmune diseases are complex, multifactorial diseases with a polygenic trait and diverse environmental factors that contribute to triggering and exacerbating each disorder. The human microbiome is increasingly implicated in the multistep pathogenesis of autoimmune diseases. We summarize here the latest developments in the field of how the microbiota
Márcia S, Pereira, Martin A, Kriegel
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Gut pathobionts as triggers for liver diseases
Nature Microbiology, 2019Klebsiella pneumoniae isolated from patients with primary sclerosing cholangitis was found to cause intestinal barrier dysfunction resulting in T-helper-17-cell-mediated hepatobiliary injury, providing evidence for specific gut-derived, pore-forming pathogens as triggers for immune-mediated liver disease.
Peter, Fickert, Hanns-Ulrich, Marschall
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Oral Pathobionts Promote MS-like Symptoms in Mice
Journal of Dental Research, 2022Dysbiotic oral microbiota has been associated with multiple sclerosis. However, the role and mechanism of oral microbiota in the development of multiple sclerosis are still elusive. Here, we demonstrated that ligature-induced periodontitis (LIP) aggravated experimental autoimmune encephalomyelitis (EAE) in mice, and this was likely dependent on the ...
L.-J. Zhou +10 more
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Metabolism of periodontal pathobionts: Their regulatory roles in the dysbiotic microbiota
Molecular Oral Microbiology, 2023Abstract The onset and development of periodontitis centers around microbiota dysbiosis and disrupted host responses. Dynamic metabolic activities of the subgingival microbiota modify the polymicrobial community, shape the microenvironment, and modulate the host response.
Jing, Ding, Chuanjiang, Zhao, Li, Gao
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