Results 231 to 240 of about 4,917 (252)
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Pathobiont hypnotises enterocytes to promote tumour development
Gut, 2014Cougnoux and colleagues1 report a new mechanism by which select bacteria can drive colon cancer. Specifically, they discovered that colobactin-producing E. coli strains can activate growth-arrested (ie, senescent) cells to produce growth factors that drive tumor growth.
Benoit, Chassaing, Andrew T, Gewirtz
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Host–pathobiont interactions in Crohn’s disease
Nature Reviews Gastroenterology & HepatologyThe mammalian intestine is colonized by trillions of microorganisms that are collectively referred to as the gut microbiota. The majority of symbionts have co-evolved with their host in a mutualistic relationship that benefits both. Under certain conditions, such as in Crohn's disease, a subtype of inflammatory bowel disease, some symbionts bloom to ...
Roberta Caruso +3 more
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A lung pathobiont story: Thinking outside the Koch’s postulate box
Cell Host & Microbe, 2022Li et al., demonstrate how Neisseria spp., thought to be a commensal, can play a pathogenic role in bronchiectasis. Here, we discuss how our thinking has evolved from the classical Koch's postulates to a complex network of microbial-host interactions and their role in disease pathogenesis.
Shivani, Singh, Leopoldo N, Segal
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Pathobionts in the microbiome: Drivers of disease and targets for treatment
Microbial PathogenesisPathobionts are commensal inhabitants of the human microbiome that can transition to a pathogenic state under specific genetic or environmental conditions. They have recently gained attention for their impact on various clinical conditions. This review discusses the key factors behind pathobiont emergence, including microbial dysbiosis, antibiotic use,
Selvaraj Bharathi +4 more
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An intestinal arsonist: pathobiont ignites IBD and flees the scene
Gut, 2013Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic conditions characterised by recurrent episodes of intestinal inflammation. It is widely accepted that genetic predisposition and environmental factors contribute to the onset and the development of IBD.
Stefan, Jellbauer, Manuela, Raffatellu
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Commensals can become pathobionts
Journal of Clinical Periodontology, 2021Sok‐Ja Janket +3 more
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Commensal microbiota as possible pathobiont in autoinflammatory disease
The Journal of Immunology, 2019Abstract The ocular surface has an associated microbiome that contributes to maintenance of local immune homeostasis and protects the ocular surface from fungal and bacterial infections. However, in individuals with a dysregulated immune response, commensal flora could cause pathology.
Jay Siak +7 more
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How infection-triggered pathobionts influence virulence evolution
Philosophical Transactions of the Royal Society B: Biological SciencesHost–pathogen interactions can be influenced by the host microbiota, as the microbiota can facilitate or prevent pathogen infections. In addition, members of the microbiota can become virulent. Such pathobionts can cause co-infections when a pathogen infection alters the host immune system and triggers dysbiosis.
Mathias Franz +2 more
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The role of oral pathobionts in the pathogenesis of gastrointestinal inflammation
The Journal of Immunology, 2019Abstract Mounting evidence suggests that gut microbiota contributes to the pathogenesis of inflammatory bowel disease (IBD). However, the identity of disease-associated pathobionts is unknown. Recent studies showed that patients with IBD are colonized by atypical bacterial members, particularly those residing in the oral cavity (e.g ...
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