Results 211 to 220 of about 5,803 (234)

Oral Pathobionts Promote MS-like Symptoms in Mice

Journal of Dental Research, 2022
Dysbiotic oral microbiota has been associated with multiple sclerosis. However, the role and mechanism of oral microbiota in the development of multiple sclerosis are still elusive. Here, we demonstrated that ligature-induced periodontitis (LIP) aggravated experimental autoimmune encephalomyelitis (EAE) in mice, and this was likely dependent on the ...
L.-J. Zhou, W.-Z. Lin, T. Liu, B.-Y. Chen, X.-Q. Meng, Y.-L. Li, L.-J. Du, Y. Liu, Y.-C. Qian, Y.-Q. Zhu, S.-Z. Duan   +10 more
openaire   +2 more sources

Metabolism of periodontal pathobionts: Their regulatory roles in the dysbiotic microbiota

Molecular Oral Microbiology, 2023
Abstract The onset and development of periodontitis centers around microbiota dysbiosis and disrupted host responses. Dynamic metabolic activities of the subgingival microbiota modify the polymicrobial community, shape the microenvironment, and modulate the host response.
Jing, Ding, Chuanjiang, Zhao, Li, Gao
openaire   +2 more sources

Diet–Pathobiont Interplay in Health and Inflammatory Bowel Disease

Trends in Microbiology
The intestinal microbiota plays a crucial role in maintaining host health by participating in various beneficial functions. However, under certain conditions, it can contribute to the development of inflammatory bowel disease (IBD) and other chronic inflammatory conditions.
Héloïse Rytter, Benoit Chassaing
exaly   +3 more sources

Host–pathobiont interactions in Crohn’s disease

Nature Reviews Gastroenterology & Hepatology
The mammalian intestine is colonized by trillions of microorganisms that are collectively referred to as the gut microbiota. The majority of symbionts have co-evolved with their host in a mutualistic relationship that benefits both. Under certain conditions, such as in Crohn's disease, a subtype of inflammatory bowel disease, some symbionts bloom to ...
Roberta Caruso, Bernard C. Lo, Grace Y. Chen, Gabriel Núñez   +3 more
openaire   +2 more sources

Pathobiont hypnotises enterocytes to promote tumour development

Gut, 2014
Cougnoux and colleagues1 report a new mechanism by which select bacteria can drive colon cancer. Specifically, they discovered that colobactin-producing E. coli strains can activate growth-arrested (ie, senescent) cells to produce growth factors that drive tumor growth.
Benoit, Chassaing, Andrew T, Gewirtz
openaire   +2 more sources

Pathobionts in the microbiome: Drivers of disease and targets for treatment

Microbial Pathogenesis
Pathobionts are commensal inhabitants of the human microbiome that can transition to a pathogenic state under specific genetic or environmental conditions. They have recently gained attention for their impact on various clinical conditions. This review discusses the key factors behind pathobiont emergence, including microbial dysbiosis, antibiotic use,
Selvaraj Bharathi, Yolin Angel P.A. Soundara Rajan, Santhiyagu Prakash, Grasian Immanuel, Ramasamy Ramasubburayan   +4 more
openaire   +2 more sources

An intestinal arsonist: pathobiont ignites IBD and flees the scene

Gut, 2013
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic conditions characterised by recurrent episodes of intestinal inflammation. It is widely accepted that genetic predisposition and environmental factors contribute to the onset and the development of IBD.
Stefan, Jellbauer, Manuela, Raffatellu
openaire   +2 more sources

Commensals can become pathobionts

Journal of Clinical Periodontology, 2021
Sok‐Ja Janket, Harry A. Conte, Jukka H. Meurman, Eleftherios P. Diamandis   +3 more
openaire   +2 more sources

Commensal microbiota as possible pathobiont in autoinflammatory disease

The Journal of Immunology, 2019
Abstract The ocular surface has an associated microbiome that contributes to maintenance of local immune homeostasis and protects the ocular surface from fungal and bacterial infections. However, in individuals with a dysregulated immune response, commensal flora could cause pathology.
Jay Siak, Anthony St. Leger, Kumarkrishna Raychaudhuri, Mary Mattapallil, Ivan J Fuss, Raphaela Goldbach-Mansky, Warren Strober, Rachel R Caspi   +7 more
openaire   +1 more source

How infection-triggered pathobionts influence virulence evolution

Philosophical Transactions of the Royal Society B: Biological Sciences
Host–pathogen interactions can be influenced by the host microbiota, as the microbiota can facilitate or prevent pathogen infections. In addition, members of the microbiota can become virulent. Such pathobionts can cause co-infections when a pathogen infection alters the host immune system and triggers dysbiosis.
Mathias Franz, Roland R. Regoes, Jens Rolff   +2 more
openaire   +2 more sources