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Evolving concepts of host–pathobiont interactions in autoimmunity
Current Opinion in Immunology, 2023Autoimmune diseases are complex, multifactorial diseases with a polygenic trait and diverse environmental factors that contribute to triggering and exacerbating each disorder. The human microbiome is increasingly implicated in the multistep pathogenesis of autoimmune diseases. We summarize here the latest developments in the field of how the microbiota
Márcia S, Pereira, Martin A, Kriegel
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Oral Pathobionts Promote MS-like Symptoms in Mice
Journal of Dental Research, 2022Dysbiotic oral microbiota has been associated with multiple sclerosis. However, the role and mechanism of oral microbiota in the development of multiple sclerosis are still elusive. Here, we demonstrated that ligature-induced periodontitis (LIP) aggravated experimental autoimmune encephalomyelitis (EAE) in mice, and this was likely dependent on the ...
L.-J. Zhou +10 more
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Gut pathobionts as triggers for liver diseases
Nature Microbiology, 2019Klebsiella pneumoniae isolated from patients with primary sclerosing cholangitis was found to cause intestinal barrier dysfunction resulting in T-helper-17-cell-mediated hepatobiliary injury, providing evidence for specific gut-derived, pore-forming pathogens as triggers for immune-mediated liver disease.
Peter, Fickert, Hanns-Ulrich, Marschall
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Pathobiont hypnotises enterocytes to promote tumour development
Gut, 2014Cougnoux and colleagues1 report a new mechanism by which select bacteria can drive colon cancer. Specifically, they discovered that colobactin-producing E. coli strains can activate growth-arrested (ie, senescent) cells to produce growth factors that drive tumor growth.
Benoit, Chassaing, Andrew T, Gewirtz
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Host–pathobiont interactions in Crohn’s disease
Nature Reviews Gastroenterology & HepatologyThe mammalian intestine is colonized by trillions of microorganisms that are collectively referred to as the gut microbiota. The majority of symbionts have co-evolved with their host in a mutualistic relationship that benefits both. Under certain conditions, such as in Crohn's disease, a subtype of inflammatory bowel disease, some symbionts bloom to ...
Roberta Caruso +3 more
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Within-host evolution of a gut pathobiont facilitates liver translocation
Nature, 2022Gut commensal bacteria with the ability to translocate across the intestinal barrier can drive the development of diverse immune-mediated diseases1-4. However, the key factors that dictate bacterial translocation remain unclear. Recent studies have revealed that gut microbiota strains can adapt and evolve throughout the lifetime of the host5-9, raising
Yi Yang +7 more
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How infection-triggered pathobionts influence virulence evolution
Philosophical Transactions of the Royal Society B: Biological SciencesHost–pathogen interactions can be influenced by the host microbiota, as the microbiota can facilitate or prevent pathogen infections. In addition, members of the microbiota can become virulent. Such pathobionts can cause co-infections when a pathogen infection alters the host immune system and triggers dysbiosis.
Mathias Franz +2 more
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A lung pathobiont story: Thinking outside the Koch’s postulate box
Cell Host & Microbe, 2022Li et al., demonstrate how Neisseria spp., thought to be a commensal, can play a pathogenic role in bronchiectasis. Here, we discuss how our thinking has evolved from the classical Koch's postulates to a complex network of microbial-host interactions and their role in disease pathogenesis.
Shivani, Singh, Leopoldo N, Segal
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Commensals can become pathobionts
Journal of Clinical Periodontology, 2021Sok‐Ja Janket +3 more
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