Results 61 to 70 of about 6,734 (227)

Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]

, 2019
Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland, Fromm, Anja, Fromm, Michael, Gorkiewicz, Gregor, Hering, Nina A., Högenauer, Christoph, Schulzke, Jörg-Dieter, Troeger, Hanno, Zechner, Ellen   +8 more
core   +1 more source

Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases [PDF]

, 2014
The incidence of inflammatory bowel diseases (IBD), as well as other inflammatory conditions, has dramatically increased over the past half century. While many studies have shown that IBD exhibits a genetic component via genome-wide association studies ...
Chang, Eugene B., Devkota, Suzanne, Leone, Vanessa   +2 more
core   +1 more source

The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation

Immune Network, 2020
An excessive hyperinflammatory response-caused septic shock is a major medical problem that is associated with pathogenic bacterial infections leading to high mortality rates. The intestinal microbiota and the associated elaborated metabolites such as short chain fatty acid butyrate have been shown to relieve pathogenic bacterial-caused acute ...
Jiezhong Chen, Luis Vitetta
openaire   +2 more sources

The Complete Genome Sequence of the Murine Pathobiont Helicobacter typhlonius [PDF]

Frontiers in Microbiology, 2016
Immuno-compromised mice infected with Helicobacter typhlonius are used to model microbially inducted inflammatory bowel disease (IBD). The specific mechanism through which H. typhlonius induces and promotes IBD is not fully understood. Access to the genome sequence is essential to examine emergent properties of this organism, such as its pathogenicity.
Jeroen eFrank, Celia eDingemanse, Arnoud M. Schmitz, Rolf H. A. M. Vossen, Gert-Jan B. van Ommen, Johan T. den Dunnen, Johan T. den Dunnen, Johan T. den Dunnen, Els C. Robanus-Maandag, Seyed Yahya eAnvar, Seyed Yahya eAnvar   +10 more
openaire   +4 more sources

Antimicrobial resistance in enteric bacteria: current state and next-generation solutions

Gut Microbes, 2020
Antimicrobial resistance is one of the largest threats to global health and imposes substantial burdens in terms of morbidity, mortality, and economic costs.
M. J. Wallace, S. R. S. Fishbein, G. Dantas   +2 more
doaj   +1 more source

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Virulence behavior of uropathogenic Escherichia coli strains in the host model Caenorhabditis elegans [PDF]

, 2018
Urinary tract infections (UTIs) are among the most common bacterial infections in humans. Although a number of bacteria can cause UTIs, most cases are due to infection by uropathogenic Escherichia coli (UPEC).
Amos, Anastasi, Anyanful, Barber, Barnich, Beutin, Blango, Brennan, Brenner, Brzuszkiewicz, Burton, Caldwell, Chen, Chávez, Chávez, Clermont, Croxen, Dale, Dho-Moulin, Diard, Doonan, Edgar, Ewers, Ferrières, Foxman, Francisco, Fricke, Guyer, Hagberg, Hoeven, Hornef, Johnson, Johnson, Johnson, Johnson, Kampkötter, Kaper, Kim, King, Kӧhler, Longhi, Mahajan-Miklos, Manges, Martinez-Medina, Merkx-Jacques, Mi, Mobley, Mulvey, Mylonakis, Müller, Paiva, Pidgeon, Powell, Sifri, Soto, Stepanović, Tan, Thumbikat, Valdivia, Wirth, Zanni   +60 more
core   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source

NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease. [PDF]

, 2017
Inflammasomes are cytosolic multiprotein complexes that initiate protective immunity in response to infection, and can also drive auto-inflammatory diseases, but the cell types and signalling pathways that cause these diseases remain poorly understood ...
Nichols, Randilea D, Vance, Russell E, von Moltke, Jakob   +2 more
core   +2 more sources