Results 111 to 120 of about 118,779 (271)

Development and validation of a 3D similarity method for virtual screening [PDF]

, 2013
A predictive 3D similarity workflow approach has been developed using a set of modular Java computer programs that implement algorithms that aim to capture the key components of a 3D similarity search and aim to incorporate methods that address both ...
Butler, Daniel
core  

Transcriptomics of In Vitro Immune-Stimulated Hemocytes from the Manila Clam Ruditapes philippinarum Using High-Throughput Sequencing

, 2012
The Manila clam (Ruditapes philippinarum) is a worldwide cultured bivalve species with important commercial value. Diseases affecting this species can result in large economic losses.
Beatriz Novoa, Pablo Balseiro, Moreira, Rebeca, Figueras Huerta, Antonio, Rebeca Moreira, Antonio Figueras, Moreira Rebeca, Berta Fuste, Pablo Balseiro (164432), Beltran i Agulló, Sergi, Balseiro Pablo, Planas, Josep V., Novoa, Beatriz, Josep V Planas, Sergi Beltran, Rebeca Moreira (170749), Berta Fuste (164457), Beltran Sergi, Fusté, Berta, Beltrán, Sergi, Antonio Figueras (82634), Planas Vilarnau, Josep, Beatriz Novoa (82631), Figueras, Antonio, Josep V. Planas (105540), Fuste Berta, Sergi Beltran (25221), Balseiro, P., Figueras Antonio, Planas Josep V., Novoa Beatriz, Balseiro, Pablo   +31 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Engineering plant resistance by constructing chimeric receptors that recognize damage-associated molecular patterns (DAMPs)

, 2011
An efficient sensing of danger and a rapid activation of the immune system are crucial for the survival of plants. Conserved pathogen/microbe-associated molecular patterns (PAMPs/MAMPs) and endogenous molecular patterns, which are present only when the ...
DE LORENZO, Giulia, Giulia De Lorenzo, SICILIA, Francesca, Daniel Valentin Savatin, Felice Cervone, SAVATIN, DANIEL VALENTIN, Francesca Sicilia, Brutus, Alexandre, CERVONE, Felice, Alexandre Brutus   +9 more
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

The Cladosporium fulvum Avr2 protein behaves both as a virulence and an avirulence factor

, 2010
Plants are not able to move or escape and have to confront environmental challenges like nutrient and water deprivation, low and high temperatures, and biotic stress imposed by pathogens like viruses, bacteria, fungi, nematodes and insects that all ...
van t Klooster, J.W., Klooster, J.W., van t   +1 more
core  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Inflammasomes: Pandora’s box for sepsis

Journal of Inflammation Research, 2018
Vijay Kumar1,2 1Children’s Health Queensland Clinical Unit, School of Clinical Medicine, Faculty of Medicine, Mater Research, University of Queensland, Brisbane, Australia; 2School of Biomedical Sciences, Faculty of Medicine, University of ...
Kumar V
doaj  

Biotic and abiotic stress management in agriculture: The transformative role of nanotechnology

Plant Nano Biology
Phyto-pathogen interactions significantly affect plant growth, yield, and agricultural productivity. Over recent decades, genetic and molecular studies have unraveled the complexity of plant immune mechanisms, focusing on the interplay between plant ...
Anshuman Shah, Shaily Tyagi, Ravi Kant Singh, Kapil K. Tiwari, Gangwar G. Prasad, Sanjay Kalia, Rajeev Kumar, Vandna Rai   +7 more
doaj   +1 more source