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Intestinal Barrier and Pathogen-Associated Molecular Patterns (PAMPs) in the Development and Therapy of Alcohol-Related Liver Disease

2023
Alcohol consumption is still among the leading causes of liver damage world-wide. Molecular mechanisms of the development of alcohol-related liver diseases (ALD) are still not fully understood, however, several studies suggest an important role of alcohol-mediated changes in intestinal barrier function and the interaction with the liver (gut-liver-axis)
Jung, Finn   +2 more
openaire   +1 more source

Chemokine production and pattern recognition receptor (PRR) expression in whole blood stimulated with pathogen-associated molecular patterns (PAMPs)

Cytokine, 2005
Recognition of conserved bacterial structures called pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs), may lead to induction of a variety of "early immediate genes" such as chemokines. In the current study, we have in an ex vivo whole blood model studied the induction of the chemokines MIP-1alpha, MCP-1 and IL-8 by
Anne-Sophie W, Møller   +5 more
openaire   +2 more sources

Synthetic Anti-lipopolysaccharide Peptides (SALPs) as Effective Inhibitors of Pathogen-Associated Molecular Patterns (PAMPs)

2019
Antimicrobial peptides (AMPs) are in the focus of scientific research since the 1990s. In most cases, the main aim was laid on the design of AMP to kill bacteria effectively, with particular emphasis on broadband action and independency on antibiotic resistance. However, so far no approved drug on the basis of AMP has entered the market.Our approach of
Wilmar, Correa   +12 more
openaire   +2 more sources

Spermine inhibits pathogen-associated molecular pattern (PAMP) ROS and Ca 2+ burst and reshapes the transcriptional landscape of PAMP-triggered immunity in Arabidopsis thaliana

2022
ABSTRACT Polyamines are small polycationic amines which levels increase during defense. Previous studies support the contribution of the polyamine spermine (Spm) to the establishment of the hypersensitive response (HR) during incompatible plant-pathogen interactions. However, the potential contribution of Spm to other
Chi Zhang   +2 more
openaire   +1 more source

Galectins in innate immunity: dual functions of host soluble β‐galactoside‐binding lectins as damage‐associated molecular patterns (DAMPs) and as receptors for pathogen‐associated molecular patterns (PAMPs)

Immunological Reviews, 2009
Summary:  The glycocalyx is a glycan layer found on the surfaces of host cells as well as microorganisms and enveloped virus. Its thickness may easily exceed 50 nm. The glycocalyx does not only serve as a physical protective barrier but also contains various structurally different glycans, which provide cell‐ or microorganism‐specific ‘glycoinformation’
Sachiko, Sato   +3 more
openaire   +2 more sources

M-ficolin, a monocyte pathogen-associated molecular pattern (PAMP) recognition molecule (PRM)

Molecular Immunology, 2009
Steffen Thiel   +4 more
openaire   +1 more source

Pathogen-Associated Molecular Patterns (PAMPs)

2014
Sandro Silva-Gomes   +2 more
openaire   +1 more source

Pathogen-Associated Molecular Patterns (PAMP) and PAMP-Triggered Immunity

2009
Thorsten Nrnberger, Birgit Kemmerling
openaire   +1 more source

INNATE IMMUNE GENE DISCOVERY USING MACROPHAGE RESPONSE TO PATHOGEN-ASSOCIATED MOLECULAR PATTERNS (PAMPS)

A31. INNATE IMMUNE REGULATION OF AIRWAY INFLAMMATION: ROLE OF DENDRITIC CELLS AND MACROPHAGES, 2010
Ivana V. Yang   +11 more
openaire   +1 more source

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