Results 41 to 50 of about 11,620,757 (255)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The impact of pathogen reduction on ABO isoagglutinin titers in apheresis platelets

Hematology, Transfusion and Cell Therapy
Background: Platelet transfusions are a cornerstone of modern medical care, used across various clinical contexts. Ensuring the compatibility of blood products, especially regarding ABO isoagglutinins, is critical to minimize adverse reactions.
Mikayel Yeghiazaryan, Yembur Ahmad, Jessie Singer, Vaanush Nazaryan, Craig Fletcher, Yamac Akgun   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Ultrastructure of human platelet concentrates after treatment with pathogen reduction technologies for prolonged storage

Frontiers in Medicine
Background and objectivesPathogen reduction technologies (PRTs) increase blood supply safety but may also increase platelet storage lesion, probably due to mitochondrial DNA damage.
Mohammed Barham, Tobias Odenthal, Susanne M. Picker, Andrea Grandoch, Birgit S. Gathof, Wolfram F. Neiss   +5 more
doaj   +1 more source

The Utility of Data Transformation for Alignment, De Novo Assembly and Classification of Short Read Virus Sequences

Viruses, 2019
Advances in DNA sequencing technology are facilitating genomic analyses of unprecedented scope and scale, widening the gap between our abilities to generate and fully exploit biological sequence data.
Avraam Tapinos, Bede Constantinides, My V. T. Phan, Samaneh Kouchaki, Matthew Cotten, David L. Robertson   +5 more
doaj   +1 more source

Cold Plasma Treatment Strategies for the Control of Fusarium oxysporum f. sp. basilici in Sweet Basil

HortScience, 2020
Fusarium wilt of basil (FOB), caused by Fusarium oxysporum f. sp. basilici, is an economically damaging disease of field- and greenhouse-grown sweet basil. Growers have observed a resurgence of FOB and susceptibility in FOB-resistant cultivars.
Kathryn Homa, William P. Barney, William P. Davis, Daniel Guerrero, Mary J. Berger, Jose L. Lopez, Christian A. Wyenandt, James E. Simon   +7 more
doaj   +1 more source

Pathogen reduction of monkeypox virus in plasma and whole blood using riboflavin and UV light.

PLoS ONE, 2023
BackgroundMonkeypox virus has recently emerged from endemic foci in Africa and, since October 20, 2022, more than 73,000 human infections have been reported by the CDC from over 100 countries that historically have not reported monkeypox cases.
Izabela K Ragan, Lindsay M Hartson, Elizabeth J Sullivan, Richard A Bowen, Raymond P Goodrich   +4 more
doaj   +1 more source

Killing them softly:managing pathogen polymorphism and virulence in spatially variable environments [PDF]

, 2013
Understanding why pathogen populations are genetically variable is vital because genetic variation fuels evolution, which often hampers disease control efforts.
Vale, Pedro F; id_orcid, Vale, Pedro F.
core   +1 more source

Pathogen reduction across different vaccine infectious periods.

, 2023
Level of pathogen reduction achieved across various times of vaccination with different vaccine recovery rates indicated by the different colors. The vaccine recovery rate controls the length of time that the vaccine can disseminate to other individuals ...
Andrew Basinski (5204810), Courtney Schreiner (13447382), Scott Nuismer (3576926), Christopher Remien (16851685)   +3 more
core   +1 more source