Results 61 to 70 of about 11,620,757 (255)

The Mirasol Evaluation of Reduction in Infections Trial (MERIT): study protocol for a randomized controlled clinical trial

Trials, 2022
Background Transfusion-transmitted infections (TTIs) are a global health challenge. One new approach to reduce TTIs is the use of pathogen reduction technology (PRT).
Ronnie Kasirye, Heather A. Hume, Evan M. Bloch, Irene Lubega, Dorothy Kyeyune, Ruchee Shrestha, Henry Ddungu, Hellen Wambongo Musana, Aggrey Dhabangi, Joseph Ouma, Priscilla Eroju, Telsa de Lange, Michael Tartakovsky, Jodie L. White, Ceasar Kakura, Mary Glenn Fowler, Philippa Musoke, Monica Nolan, M. Kate Grabowski, Lawrence H. Moulton, Susan L. Stramer, Denise Whitby, Peter A. Zimmerman, Deo Wabwire, Isaac Kajja, Jeffrey McCullough, Raymond Goodrich, Thomas C. Quinn, Robert Cortes, Paul M. Ness, Aaron A. R. Tobian   +30 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Options for dust reduction from poultry houses [PDF]

, 2009
Large poultry houses emit high amounts of fine dust (PM10) and in many cases they exceed the ambient air quality standard set by the EU. Technologies for PM10 reduction need to be developed on short term to minimize PM10 emissions from poultry houses ...
de Buisonjé, F.E., Harn, J., van, Winkel, A., Aarnink, A.J.A., van Harn, J., Cambra-López, M., Mosquera, J., Buisonjé, F.E., de, Ogink, N.W.M.   +8 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Application value and challenges associated with plasma cell-free DNA metagenomic sequencing technology in the diagnosis of infections in patients with hematological disorders

Blood Science
In patients with hematological disorders, the high risk of complex infections caused by immune dysfunction and intensive therapies poses a major challenge to the use of conventional microbiological tests (CMTs).
Chunhui Xu, Teng Liu, Xuyan Zhang, Sizhou Feng   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Balancing Selection at the Tomato RCR3 Guardee Gene Family Maintains Variation in Strength of Pathogen Defense [PDF]

, 2012
Coevolution between hosts and pathogens is thought to occur between interacting molecules of both species. This results in the maintenance of genetic diversity at pathogen antigens (or so-called effectors) and host resistance genes such as the major ...
Anja C. Hörger, Rose, Laura E., Renier A. L. Van Der, Renier A. L. van der Hoorn (150148), Van Der Hoorn, RAL, van der Hoorn, RA, Hoerger, A., Rose, LE, Van der Hoorn, R., Muhammad Ilyas, Laura E Rose, Ilyas, M, Laura E. Rose (150153), Hörger, Anja C., Laura E. Rose, Hoerger, AC, Rose, L., Aurélien Tellier, Van Der Hoorn, Renier, Stephan, Wolfgang, Hörger, AC, Tellier, A, Tellier, A., Muhammad Ilyas (150134), Anja C Hörger, van der Hoorn, Renier A. L., Anja C. Hörger (150127), Tellier, Aurélien, Stephan, W., Wolfgang Stephan (14960), Aurélien Tellier (150142), Renier A L van der Hoorn, Wolfgang Stephan, Stephan, W, Ilyas, M., Ilyas, Muhammad, van der Hoorn Renier A. L., Rose Laura E., Tellier Aurélien, Stephan Wolfgang, Hörger, Anja C.;Ilyas, Muhammad;Stephan, Wolfgang;Tellier, Aurélien;van der Hoorn, Renier A. L.;Rose, Laura E., Ilyas Muhammad, Hörger Anja C.   +42 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Structural Change in the Meat and Poultry Industry and the Pathogen Reduction Hazard Analysis Critical Control Point Rule [PDF]

This paper uses plant-level micro-data covering the 1987-2002 and a translog cost function to estimate long-run costs in the meat and poultry industry in order to evaluate the impact of the Pathogen Reduction Hazard Analysis Critical Control Point Rule ...
Ollinger, Michael
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