Results 51 to 60 of about 11,620,757 (255)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

SUPERSEDED - Data for "Transmission from vaccinated hosts can cause dose-dependent reduction in pathogen virulence"

, 2020
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2725 . ## # Abstract # Many livestock and increasingly human vaccines are leaky, blocking symptoms without preventing infection or onward transmission ...
Chase-Topping, Margo, Doeschl-Wilson, Andrea, Mays, Jody, Dunn, John R, Cheng, Hans H, Anacleto, Osvaldo, Bailey, Richard I   +6 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evaluation of the efficacy and safety of amustaline/glutathione pathogen-reduced RBCs in complex cardiac surgery: the Red Cell Pathogen Inactivation (ReCePI) study—protocol for a phase 3, randomized, controlled trial

Trials, 2023
Background Red blood cell (RBC) transfusion is a critical supportive therapy in cardiovascular surgery (CVS). Donor selection and testing have reduced the risk of transfusion-transmitted infections; however, risks remain from bacteria, emerging viruses ...
Edward L. Snyder, Michael E. Sekela, Ian J. Welsby, Yoshiya Toyoda, Mohamed Alsammak, Neel R. Sodha, Thomas M. Beaver, J. Peter R. Pelletier, James D. Gorham, John S. McNeil, Roman M. Sniecinski, Ronald G. Pearl, Gregory A. Nuttall, Ravi Sarode, T. Brett Reece, Alesia Kaplan, Robertson D. Davenport, Tina S. Ipe, Peyman Benharash, Ileana Lopez-Plaza, Richard R. Gammon, Patrick Sadler, John P. Pitman, Kathy Liu, Stanley Bentow, Laurence Corash, Nina Mufti, Jeanne Varrone, Richard J. Benjamin, for the ReCePI study group   +29 more
doaj   +1 more source

Intestinal inflammation responds to microbial tissue load independent of pathogen/non-pathogen discrimination [PDF]

, 2012
The intestinal immune system mounts inflammatory responses to pathogens but tolerates harmless commensal microbiota. Various mechanisms for pathogen/non-pathogen discrimination have been proposed but their general relevance for inflammation control is ...
Dirk Bumann (126124), Dirk Bumann, Yvonne Willer (126110), Willer, Yvonne, Willer Yvonne, Müller, Beatrice, Bumann, D., Yvonne Willer, Willer, Y., Beatrice Müller, Müller Beatrice, Müller, B., Bumann, Dirk, Bumann Dirk, Beatrice Müller (166158)   +14 more
core   +2 more sources

Pathogen reduction across different host lifespans.

, 2023
Level of pathogen reduction achieved across various times of vaccination with different average host lifespans indicated by the different colors. Solid lines represent the level of pathogen reduction achieved for a given date of vaccine introduction ...
Andrew Basinski (5204810), Courtney Schreiner (13447382), Scott Nuismer (3576926), Christopher Remien (16851685)   +3 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A generic pathogen capture technology for sepsis diagnosis [PDF]

, 2013
Thesis (Ph. D. in Medical and Engineering Physics)--Harvard-MIT Program in Health Sciences and Technology, June 2013."May 2013." Cataloged from PDF version of thesis.Includes bibliographical references (pages 121-127).Sepsis is a systemic inflammatory ...
Cooper, Ryan Mcomber
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Down-regulation of Fusarium oxysporum endogenous genes by Host-Delivered RNA interference enhances disease resistance

Frontiers in Chemistry, 2015
Fusarium oxysporum is a devastating pathogen causing extensive yield losses in a variety of crops and development of sustainable, environmentally friendly methods to improve crop resistance is crucial. We have used Host-Derived RNA interference (HD-RNAi)
Zongli eHu, Zongli eHu, Urvi eParekh, Natsumi eMaruta, Yuri eTrusov, Jimmy R Botella   +5 more
doaj   +1 more source