Results 21 to 30 of about 253,129 (246)
V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission
eLife, 2021 Membrane fission, the division of a membrane-bound structure into two discrete compartments, is essential for diverse cellular events, such as endocytosis and vesicle/granule biogenesis; however, the process remains unclear.
Yasuo Yamazaki, Yuka Eura, Koichi Kokame
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Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase
Signal Transduction and Targeted Therapy, 2023 CD4+ T cells, particularly IL-17-secreting helper CD4+ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8+ T cells and has important implications in ...
Hao-Yun Peng +9 more
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Microorganisms, 2022 South American camelids (SAC) are increasingly kept in Europe in close contact with humans and other livestock species and can potentially contribute to transmission chains of epizootic, zoonotic and antimicrobial-resistant (AMR) agents from and to ...
Belén González-Santamarina +3 more
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Nature Communications, 2023 Three types of DNA methyl modifications have been detected in bacterial genomes, and mechanistic studies have demonstrated roles for DNA methylation in physiological functions ranging from phage defense to transcriptional control of virulence and host ...
Michael J. Tisza +6 more
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A case report of multiple primary prostate tumors with differential drug sensitivity
Nature Communications, 2020 Prostate cancer is often a multifocal disease but how best to manage this clinically remains unclear. Here, the authors report a single case study of a patient with two genetically diverse tumours which showed differential response to therapy.
Scott Wilkinson +20 more
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Valganciclovir as Add-On to Standard Therapy in Secondary Glioblastoma
Microorganisms, 2020 Patients with glioblastoma have a very poor prognosis despite aggressive therapeutic strategies. Cytomegalovirus has been detected in >90% of glioblastoma tumors.
Giuseppe Stragliotto +3 more
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Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats
Arthritis Research & Therapy, 2022 Background Light alteration affects the internal environment and metabolic homeostasis of the body through circadian rhythm disorders (CRD). CRD is one of the factors that induce and accelerate osteoarthritis (OA). Therefore, the aim of this study was to
Xiaopeng Song +15 more
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Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999 An increasing number of neurodegenerative disorders have been found to be caused by expanding CAG triplet repeats that code for polyglutamine. Huntington's disease (HD) is the most common of these disorders and dentato-rubral-pallidoluysian atrophy (DRPLA) is very similar to HD, but is caused by mutation in a different gene, making them good models to ...
C A, Ross +8 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Journal of Biological Engineering, 2019 Background The promise of biopharmaceuticals comprising one or more binding domains motivates the development of novel methods for de novo isolation and affinity maturation of virion-binding domains.
Pete Heinzelman +4 more
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