Results 31 to 40 of about 1,701,047 (213)

Pathogenesis, Immunology and Management of Dermatophytosis [PDF]

, 2021
Dermatophytic infections of the skin and appendages are a common occurrence. The pathogenesis involves complex interplay of agent (dermatophytes), host (inherent host defense and host immune response) and the environment.
Clay J. Cockerell, Anant Patil, Stephan Grabbe, Robert A. Schwartz, Mohamad Goldust, Yaser Goldust, Shishira R. Jartarkar   +6 more
core   +1 more source

NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease

Nature Communications, 2017
Inflammasomes are protein complexes induced by pathogens for the secretion of pro-inflammatory cytokines IL-1β and IL-18 in immune cells. Here the authors show, using a new mouse model, that aberrant NLRC4 and ASC-dependent inflammasome activation in ...
Randilea D. Nichols, Jakob von Moltke, Russell E. Vance   +2 more
doaj   +1 more source

V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission

eLife, 2021
Membrane fission, the division of a membrane-bound structure into two discrete compartments, is essential for diverse cellular events, such as endocytosis and vesicle/granule biogenesis; however, the process remains unclear.
Yasuo Yamazaki, Yuka Eura, Koichi Kokame
doaj   +1 more source

Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence [PDF]

, 2010
The severity of respiratory syncytial virus (RSV) infections appears to differ with age in both humans and bovines. A primary RSV infection in naïve infants and in young calves runs a more severe course when they are 1–6 months old than in their first ...
Most, R.G., van der, Stockhofe-Zurwieden, N., Schrijver, R.S., Antonis, A.F.G., Poel, W.H.M., van der, Jong, M.C., de, Kimman, T.G.   +6 more
core   +1 more source

Roving methyltransferases generate a mosaic epigenetic landscape and influence evolution in Bacteroides fragilis group

Nature Communications, 2023
Three types of DNA methyl modifications have been detected in bacterial genomes, and mechanistic studies have demonstrated roles for DNA methylation in physiological functions ranging from phage defense to transcriptional control of virulence and host ...
Michael J. Tisza, Derek D. N. Smith, Andrew E. Clark, Jung-Ho Youn, NISC Comparative Sequencing Program, Pavel P. Khil, John P. Dekker   +6 more
doaj   +1 more source

Dendritic cells in myelodysplastic syndromes: from pathogenesis to immunotherapy [PDF]

, 2013
Myelodysplastic syndromes (MDS) are clonal disorders of the hematopoietic stem cell characterized by ineffective hematopoiesis leading to peripheral cytopenias.
Theresia M Westers, van de Loosdrecht, Arjan A., Arjan A van de Loosdrecht, Kerkhoff, Nathalie, Bontkes, Hetty J., de Gruijl, T.D., Westers, Theresia M., Kerkhoff, N., de Gruijl, Tanja D., Nathalie Kerkhoff, Shahram Kordasti, van de Loosdrecht, A.A., Westers, T.M., Bontkes, H.J., Kordasti, Shahram; id_orcid, Tanja D de Gruijl, Kordasti, S., Hetty J Bontkes   +17 more
core   +1 more source

A culturomics approach reveals cross-feeding capacity of intestinal pig bacteria upon release of inositol from phytate

Microbiome
Background Phytate is the primary phosphorus storage molecule of plants and plays a major role in animal nutrition. To enhance phosphate availability and absorption in livestock, and to reduce eutrophication by liquid manure, bacterial phytases are often
Lena-Sophie Paul, Michael Weber, Stefanie Wagner, Thilo M. Fuchs   +3 more
doaj   +1 more source

Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase

Signal Transduction and Targeted Therapy, 2023
CD4+ T cells, particularly IL-17-secreting helper CD4+ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8+ T cells and has important implications in ...
Hao-Yun Peng, Liqing Wang, Jugal Kishore Das, Anil Kumar, Darby J. Ballard, Yijie Ren, Xiaofang Xiong, Paul de Figueiredo, Jin-Ming Yang, Jianxun Song   +9 more
doaj   +1 more source

Cellular Mechanisms of Psoriasis Pathogenesis: A Systemic Review [PDF]

, 2023
Mengjun Wu,1 Chan Dai,2 Fanfan Zeng3 1Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2Department of Immunology, School of Basic Medicine,
Wu M, Dai C, Zeng F
core  

A case report of multiple primary prostate tumors with differential drug sensitivity

Nature Communications, 2020
Prostate cancer is often a multifocal disease but how best to manage this clinically remains unclear. Here, the authors report a single case study of a patient with two genetically diverse tumours which showed differential response to therapy.
Scott Wilkinson, Stephanie A. Harmon, Nicholas T. Terrigino, Fatima Karzai, Peter A. Pinto, Ravi A. Madan, David J. VanderWeele, Ross Lake, Rayann Atway, John R. Bright, Nicole V. Carrabba, Shana Y. Trostel, Rosina T. Lis, Guinevere Chun, James L. Gulley, Maria J. Merino, Peter L. Choyke, Huihui Ye, William L. Dahut, Baris Turkbey, Adam G. Sowalsky   +20 more
doaj   +1 more source