Results 41 to 50 of about 1,694,622 (312)

Pathogenesis of endocrine thyroid cancer [PDF]

, 2015
This review aims to discuss the different genetic alterations that may come about and thus give rise to thyroid cancer. The importance of understanding the pathogenesis of this disease is in the use of these genetic alterations as prognostic markers and ...
Vassallo, Josanne, Mallia, Nicola
core  

Valganciclovir as Add-On to Standard Therapy in Secondary Glioblastoma

Microorganisms, 2020
Patients with glioblastoma have a very poor prognosis despite aggressive therapeutic strategies. Cytomegalovirus has been detected in >90% of glioblastoma tumors.
Giuseppe Stragliotto, Mattia Russel Pantalone, Afsar Rahbar, Cecilia Söderberg-Nauclér   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Replication, Pathogenesis and Transmission of Pandemic (H1N1) 2009 Virus in Non-Immune Pigs [PDF]

, 2010
The declaration of the human influenza A pandemic (H1N1) 2009 (H1N1/09) raised important questions, including origin and host range [1,2]. Two of the three pandemics in the last century resulted in the spread of virus to pigs (H1N1, 1918; H3N2, 1968 ...
Essen, Stephen C., Bhudipa Choudhury, Jill Banks, Reeth, Kristien Van, Nunez, Alejandor, Garcon, Fanny, Nunez, A., Gardner, Rebecca, Van Reeth, Kristien, Bethany Nash, Brookes, Sharon M., Peter M H Heegaard, Alejandro Núñez, Foni, Emanuela, Irvine, Richard M., Foni, E., Jaime Maldonado Garcia, Stéphane Quéguiner, Emanuela Foni, Essen, Stephen C, Chiapponi, C., Larsen, Lars, Ian H Brown, Queguiner, S., Sharon M Brookes, Bublot, Michel, Slomka, M.J., Chiapponi, Chiara, Clifford, Derek, Garcia, Jaime M, Willie Loeffen, Choudhury, B., Nunez, Alejandro, Choudhury, Bhudipa, Kuntz-Simon, Gaélle, Essen, S.C., Matrosovich, M., Heegaard, P.M.H., Michel Bublot, Gardner, R., Matrosovich, Mikhail, Brookes, Sharon M, Brown, Ian H., Heegaard, Peter M. H., Fanny Garcon, Slomka, Marek J, Loeffen, Willie, Larsen, Lars Erik, Garcon, F., Loeffen, W.L.A., Heegaard, Peter MH, Irvine, R.M., Reeth, K., Banks, J., Chiara Chiapponi, Irvine, Richard M, Queguiner, Stéphane, Lars Larsen, Amanda Hanna, Kuntz-Simon, G., Brown, I.H., Banks, Jill, Richard M Irvine, Slomka, Marek J., Nash, Bethany, Garcia, Jaime Maldonado, Marek J Slomka, Nash, B., Mikhail Matrosovich, Hanna, Amanda, Stephen C Essen, Gaëlle Kuntz-Simon, Kristien Van Reeth, Derek Clifford, Rebecca Gardner, Hanna, A., Garcia, J.M., Brookes, S.M., Clifford, D., Brown, Ian H, Bublot, M., Heegaard, Peter M.H., Larsen, L.   +82 more
core   +1 more source

The Pathogenesis and Diagnosis of Pneumocystis jiroveci Pneumonia

, 2022
Pneumocystis jiroveci remains an important fungal pathogen in immunocompromised hosts. The environmental reservoir remains unknown. Pneumonia (PJP) results from airborne transmission, including in nosocomial clusters, or with reactivation after an ...
Jay A. Fishman, Anna Apostolopoulou, Apostolopoulou, Anna, Fishman, Jay A.   +3 more
core   +1 more source

De Novo Isolation & Affinity Maturation of yeast-displayed Virion-binding human fibronectin domains by flow cytometric screening against Virions

Journal of Biological Engineering, 2019
Background The promise of biopharmaceuticals comprising one or more binding domains motivates the development of novel methods for de novo isolation and affinity maturation of virion-binding domains.
Pete Heinzelman, Alyssa Low, Rudo Simeon, Gus A. Wright, Zhilei Chen   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Pathogenesis and treatment of atopic dermatitis

, 2020
This thesis reviews the various pathways and molecular entities involved in the development and progression of Atopic Dermatitis. It dismantles the core components that are implicated in the pathogenesis of this disease.
Qasim, Hafsa
core  

Seronegative spondyloarthropathies : a review : part II: genetics and pathogenesis [PDF]

, 1993
In none of the spondyloarthropathies is the pathogenesis well understood. Much of the investigation into the aetio-pathogenesis of these diseases has focused on the association with HLA-B27 and the known triggering potential of certain infectious agents.
Borg, Andrew A., Hothersall, T.E., Dawes, Peter T.   +2 more
core