Results 61 to 70 of about 1,837,939 (209)

HIV-1 transcription dominates over host gene activity at the HIV-1 integration site

mBio
Despite effective antiretroviral therapy (ART), HIV-1 persists as an integrated DNA provirus in the genome of infected cells. Host cells can regulate HIV-1 transcription at the HIV-1 integration site dependent on the location (actively transcribed genes ...
Samuel Weissman, Yang-Hui J. Yeh, Miriam Viazmenski, Rachel Kim, Jack A. Collora, Savannah Steinhauser, Ya-Chi Ho   +6 more
doaj   +1 more source

Pilot evaluation of a second-generation electronic pill box for adherence to Bedaquiline and antiretroviral therapy in drug-resistant TB/HIV co-infected patients in KwaZulu-Natal, South Africa

BMC Infectious Diseases, 2018
Background The introduction of Bedaquiline, the first new antimycobacterial drug in over 40 years, has highlighted the critical importance of medication adherence in drug-resistant tuberculosis (DR-TB) treatment to prevent amplified drug-resistance and ...
N. Bionghi, A. Daftary, B. Maharaj, Z. Msibi, K. R. Amico, G. Friedland, C. Orrell, N. Padayatchi, M. R. O’Donnell   +8 more
doaj   +1 more source

Prognostic Models for Small Hepatocellular Carcinoma Using Inflammatory Indices and Machine Learning: A Propensity Score-Matched Study

International Journal of General Medicine
Yun Cong,1,* Yi Gou,2,* Ziwei Ma,1 Wei Huang,1 Lifeng Zhang,1 Qiang Guo,1 Tuerganaili Aji,1 Yingmei Shao1 1Hepatobiliary & Hydatid Disease Department, Digestive & Vascular Surgery Center, First Affiliated Hospital of Xinjiang ...
Cong Y, Gou Y, Ma Z, Huang W, Zhang L, Guo Q, Aji T, Shao Y   +7 more
doaj  

Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis

Nature Communications, 2017
Although the locus at 3p13-14 is commonly deleted in prostate cancer, the identity of the potential driver genes is still unclear. Here, the authors, using a PTEN loss-driven prostate cancer mouse model, show that a multigenic FOXP1-SHQ1 deletion is a ...
Haley Hieronymus, Phillip J. Iaquinta, John Wongvipat, Anuradha Gopalan, Rajmohan Murali, Ninghui Mao, Brett S. Carver, Charles L. Sawyers   +7 more
doaj   +1 more source

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma [PDF]

, 2015
Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients.
Martinez-Barbera, JP
core  

Salmonella Pathogenesis in Dendritic Cells : Stealthy Approach Against Adaptive Immune Response [PDF]

, 2017
Synopsis of work done by Mayuri Gogoi (SR No. 10-09-00-10-31-11-1-08534) for the award of Ph.D. degree in the Faculty of Science, Indian Institute of Science, Bangalore, India.
Gogoi, Mayuri
core  

Glycans instructing immunity: the emerging role of altered glycosylation in clinical immunology

Frontiers in Pediatrics, 2015
Protein glycosylation is an important epigenetic modifying process affecting expression, localization, and function of numerous proteins required for normal immune function.
Jonathan J Lyons, Joshua eMilner, Sergio eRosenzweig   +2 more
doaj   +1 more source

Microbial Pathogenesis

, 2013
Texto completo. Acesso restrito. p. 37–42This study involves the comparison between the exoproteomes of two different strains of Corynebacterium pseudotuberculosis, the etiologic agent of caseous lymphadenitis in small ruminants.
Azevedo, Vasco Ariston de Carvalho, Silva, Artur Luiz da Costa da, Andrade, Hélida M., Silva, Wanderson M., Ciprandi, Alessandra, Miyoshi, Anderson, Santos, Agenor V., Seyffert, Núbia, Dorella, Fernanda Alves, Barh, Debmalya, Pimenta, Adriano Monteiro de Castro, Santos, Anderson Rodrigues dos, Pacheco, Luis Gustavo Carvalho, Castro, Thiago Luiz de Paula   +13 more
core  

Oral and middle ear delivery of otitis media standard of care antibiotics, but not biofilm-targeted antibodies, alter chinchilla nasopharyngeal and fecal microbiomes

npj Biofilms and Microbiomes
Otitis media (OM) is one of the most globally pervasive pediatric conditions. Translocation of nasopharynx-resident opportunistic pathogens like nontypeable Haemophilus influenzae (NTHi) assimilates into polymicrobial middle ear biofilms, which promote ...
Audrey F. Duff, Joseph A. Jurcisek, Nikola Kurbatfinski, Tendy Chiang, Steven D. Goodman, Lauren O. Bakaletz, Michael T. Bailey   +6 more
doaj   +1 more source

Experimental Models to Study the Pathogenesis and Treatment of Mucormycosis

Mucormycosis presents a formidable challenge to clinicians and researchers. Animal models are an essential part of the effort to decipher the pathogenesis of mucormycosis and to develop novel pharmacotherapeutics against it.
Ronen Ben-Ami
core   +1 more source