Results 81 to 90 of about 1,694,622 (312)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Salmonella Pathogenesis in Dendritic Cells : Stealthy Approach Against Adaptive Immune Response [PDF]

, 2017
Synopsis of work done by Mayuri Gogoi (SR No. 10-09-00-10-31-11-1-08534) for the award of Ph.D. degree in the Faculty of Science, Indian Institute of Science, Bangalore, India.
Gogoi, Mayuri
core  

Glycans instructing immunity: the emerging role of altered glycosylation in clinical immunology

Frontiers in Pediatrics, 2015
Protein glycosylation is an important epigenetic modifying process affecting expression, localization, and function of numerous proteins required for normal immune function.
Jonathan J Lyons, Joshua eMilner, Sergio eRosenzweig   +2 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

The role of host and microbial factors in the pathogenesis of pneumococcal bacteraemia arising from a single bacterial cell bottleneck. [PDF]

, 2014
The pathogenesis of bacteraemia after challenge with one million pneumococci of three isogenic variants was investigated. Sequential analyses of blood samples indicated that most episodes of bacteraemia were monoclonal events providing compelling ...
Gianni Pozzi, U. Koedel (7682816), Antonio Vivi, Braccini, T., Tassini, Maria, Vivi, Antonio, Rooijen, Nico van, Ricci, Susanna, Vivi, A., E. R. Moxon (7583117), Leonarda Colomba, E. Richard Moxon (6704), Maria Tassini, Furi, L., Peter W. Andrew (153608), Braccini, Tiziana, E Richard Moxon, Leonarda Colomba (177832), M. Tassini (7697396), Ricci, S., Moxon, E. Richard, T. Braccini (7682810), Koedel, U., Andrea Pammolli, Antonio Vivi (540384), Nico van Rooijen (4110211), A. S. Manso (7697387), Marco R Oggioni, L. Colomba (7697384), Pozzi, G., A. Gerlini (7697381), Marco R. Oggioni, Susanna Ricci, Colomba, L., Gianni Pozzi (26718), Colomba, Leonarda, Wang, Bo, Andrew, P.W., Oggioni, Marco R., Maria Tassini (540385), E. Richard Moxon, Tiziana Braccini (540381), Marco R. Oggioni (131416), Manso, Ana Sousa, Ana Sousa Manso (540382), Oggioni, M.R., M. R. Oggioni (7619033), Bo Wang, N. van Rooijen (7697399), Alice Gerlini (540379), van Rooijen, N., Tassini, M., Koedel, Uwe, Alice Gerlini, Bo Wang (86769), Moxon, E.R., Susanna Ricci (26719), G. Pozzi (7629911), Pammolli, Andrea, Peter W. Andrew, Pozzi, Gianni, Peter W Andrew, Ana Sousa Manso, P. W. Andrew (7607321), Nico van Rooijen, A. Vivi (7697393), Uwe Koedel (263360), Gerlini, Alice, Manso, A.S., Andrew, Peter W., S. Ricci (7682807), Uwe Koedel, Gerlini, A., Pammolli, A., Wang, B., A. Pammolli (7697390), Andrea Pammolli (540383), L. Furi (7636547), Leonardo Furi, Tiziana Braccini, Leonardo Furi (540380), Furi, Leonardo   +81 more
core   +1 more source

Prognostic Models for Small Hepatocellular Carcinoma Using Inflammatory Indices and Machine Learning: A Propensity Score-Matched Study

International Journal of General Medicine
Yun Cong,1,* Yi Gou,2,* Ziwei Ma,1 Wei Huang,1 Lifeng Zhang,1 Qiang Guo,1 Tuerganaili Aji,1 Yingmei Shao1 1Hepatobiliary & Hydatid Disease Department, Digestive & Vascular Surgery Center, First Affiliated Hospital of Xinjiang ...
Cong Y, Gou Y, Ma Z, Huang W, Zhang L, Guo Q, Aji T, Shao Y   +7 more
doaj  

Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis

Nature Communications, 2017
Although the locus at 3p13-14 is commonly deleted in prostate cancer, the identity of the potential driver genes is still unclear. Here, the authors, using a PTEN loss-driven prostate cancer mouse model, show that a multigenic FOXP1-SHQ1 deletion is a ...
Haley Hieronymus, Phillip J. Iaquinta, John Wongvipat, Anuradha Gopalan, Rajmohan Murali, Ninghui Mao, Brett S. Carver, Charles L. Sawyers   +7 more
doaj   +1 more source

Pilot evaluation of a second-generation electronic pill box for adherence to Bedaquiline and antiretroviral therapy in drug-resistant TB/HIV co-infected patients in KwaZulu-Natal, South Africa

BMC Infectious Diseases, 2018
Background The introduction of Bedaquiline, the first new antimycobacterial drug in over 40 years, has highlighted the critical importance of medication adherence in drug-resistant tuberculosis (DR-TB) treatment to prevent amplified drug-resistance and ...
N. Bionghi, A. Daftary, B. Maharaj, Z. Msibi, K. R. Amico, G. Friedland, C. Orrell, N. Padayatchi, M. R. O’Donnell   +8 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source