Results 21 to 30 of about 1,694,622 (312)

Pathogenesis of pruritus [PDF]

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2011
SummaryThe pathogenesis of acute and chronic (> 6 weeks duration) pruritus is complex and involves in the skin a network of resident cells (e. g., mast cells, keratinocytes, sensory neurons) and transient inflammatory cells (e. g., eosinophils). Though pruritus and pain show overlapping mechanisms, recent studies have provided evidence that pruritus
Sonja, Ständer, Ulrike, Raap, Elke, Weisshaar, Martin, Schmelz, Thomas, Mettang, Hermann, Handwerker, Thomas A, Luger   +6 more
openaire   +2 more sources

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease. [PDF]

, 2009
Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of cerebral malaria is poorly defined and progress in understanding the condition is severely hampered by the inability to study in detail, ante-mortem, the ...
KEVIN N. COUPER, Couper, Kevin N, Riley, Eleanor M, Hafalla, Julius CR, Brian De Souza, J., Hafalla, Julius C R, Couper, Kevin N., JULIUS C. R. HAFALLA, de Souza, J Brian, Riley, Eleanor M., ELEANOR M. RILEY, J. BRIAN de SOUZA   +11 more
core   +1 more source

TSE pathogenesis in cattle and sheep

, 2008
Many studies have been undertaken in rodents to study the pathogenesis of transmissible spongiform encephalopathies (TSE). Only a few studies have focused on the pathogenesis of bovine spongiform encephalopathy (BSE) and scrapie in their natural hosts ...
Bossers, A., Fred van Zijderveld, Lucien J.M. van Keulen, van Zijderveld, Fred, Keulen, L.J.M., van, van Keulen, L.J.M., van Zijderveld, F.G., Zijderveld, F.G., van, Bossers, Alex, van Keulen, Lucien, Alex Bossers   +10 more
core   +1 more source

Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers

Nature Communications, 2021
Understanding the mechanisms driving PI3K isoform dependency in prostate cancer can help the design of future clinical trials. Here, the authors show that gain-of-function mutations in PIK3CA or PIK3CB can confer PI3K p110 isoform dependency and that the
Ninghui Mao, Zeda Zhang, Young Sun Lee, Danielle Choi, Aura Agudelo Rivera, Dan Li, Cindy Lee, Samuel Haywood, Xiaoping Chen, Qing Chang, Guotai Xu, Hsuan-An Chen, Elisa de Stanchina, Charles Sawyers, Neal Rosen, Andrew C. Hsieh, Yu Chen, Brett S. Carver   +17 more
doaj   +1 more source

NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease

Nature Communications, 2017
Inflammasomes are protein complexes induced by pathogens for the secretion of pro-inflammatory cytokines IL-1β and IL-18 in immune cells. Here the authors show, using a new mouse model, that aberrant NLRC4 and ASC-dependent inflammasome activation in ...
Randilea D. Nichols, Jakob von Moltke, Russell E. Vance   +2 more
doaj   +1 more source

Pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2005
The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core   +1 more source

Escherichia coli resistant to the highest priority critically important fluoroquinolone or 3rd and 4th generation cephalosporin antibiotics persist in pigsties

Applied and Environmental Microbiology
Antimicrobial resistance threatens human and animal health, with antimicrobial usage being a key driver of selection, transmission, and spread of resistant bacteria.
Nicola M. Pfeifer, Michael Weber, Elisabeth Wiegand, Stefanie A. Barth, Christian Berens, Christian Menge   +5 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats

Arthritis Research & Therapy, 2022
Background Light alteration affects the internal environment and metabolic homeostasis of the body through circadian rhythm disorders (CRD). CRD is one of the factors that induce and accelerate osteoarthritis (OA). Therefore, the aim of this study was to
Xiaopeng Song, Mingchao Zhao, Jilang Tang, Tianwen Ma, Hui Bai, Xinyu Wang, Lin Liu, Ting Li, Xinyu Xu, Xuanbo Sheng, Binger Zhao, Yingying Wang, Tiantian Wang, Yingchao Guo, Xinmin Zhang, Li Gao   +15 more
doaj   +1 more source

Comparative Genomic Analysis of Antimicrobial-Resistant Escherichia coli from South American Camelids in Central Germany

Microorganisms, 2022
South American camelids (SAC) are increasingly kept in Europe in close contact with humans and other livestock species and can potentially contribute to transmission chains of epizootic, zoonotic and antimicrobial-resistant (AMR) agents from and to ...
Belén González-Santamarina, Michael Weber, Christian Menge, Christian Berens   +3 more
doaj   +1 more source