Results 21 to 30 of about 1,837,939 (209)

Pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2005
The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core   +1 more source

Escherichia coli resistant to the highest priority critically important fluoroquinolone or 3rd and 4th generation cephalosporin antibiotics persist in pigsties

Applied and Environmental Microbiology
Antimicrobial resistance threatens human and animal health, with antimicrobial usage being a key driver of selection, transmission, and spread of resistant bacteria.
Nicola M. Pfeifer, Michael Weber, Elisabeth Wiegand, Stefanie A. Barth, Christian Berens, Christian Menge   +5 more
doaj   +1 more source

Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers

Nature Communications, 2021
Understanding the mechanisms driving PI3K isoform dependency in prostate cancer can help the design of future clinical trials. Here, the authors show that gain-of-function mutations in PIK3CA or PIK3CB can confer PI3K p110 isoform dependency and that the
Ninghui Mao, Zeda Zhang, Young Sun Lee, Danielle Choi, Aura Agudelo Rivera, Dan Li, Cindy Lee, Samuel Haywood, Xiaoping Chen, Qing Chang, Guotai Xu, Hsuan-An Chen, Elisa de Stanchina, Charles Sawyers, Neal Rosen, Andrew C. Hsieh, Yu Chen, Brett S. Carver   +17 more
doaj   +1 more source

NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease

Nature Communications, 2017
Inflammasomes are protein complexes induced by pathogens for the secretion of pro-inflammatory cytokines IL-1β and IL-18 in immune cells. Here the authors show, using a new mouse model, that aberrant NLRC4 and ASC-dependent inflammasome activation in ...
Randilea D. Nichols, Jakob von Moltke, Russell E. Vance   +2 more
doaj   +1 more source

Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence [PDF]

, 2010
The severity of respiratory syncytial virus (RSV) infections appears to differ with age in both humans and bovines. A primary RSV infection in naïve infants and in young calves runs a more severe course when they are 1–6 months old than in their first ...
Most, R.G., van der, Stockhofe-Zurwieden, N., Schrijver, R.S., Antonis, A.F.G., Poel, W.H.M., van der, Jong, M.C., de, Kimman, T.G.   +6 more
core   +1 more source

A culturomics approach reveals cross-feeding capacity of intestinal pig bacteria upon release of inositol from phytate

Microbiome
Background Phytate is the primary phosphorus storage molecule of plants and plays a major role in animal nutrition. To enhance phosphate availability and absorption in livestock, and to reduce eutrophication by liquid manure, bacterial phytases are often
Lena-Sophie Paul, Michael Weber, Stefanie Wagner, Thilo M. Fuchs   +3 more
doaj   +1 more source

Roving methyltransferases generate a mosaic epigenetic landscape and influence evolution in Bacteroides fragilis group

Nature Communications, 2023
Three types of DNA methyl modifications have been detected in bacterial genomes, and mechanistic studies have demonstrated roles for DNA methylation in physiological functions ranging from phage defense to transcriptional control of virulence and host ...
Michael J. Tisza, Derek D. N. Smith, Andrew E. Clark, Jung-Ho Youn, NISC Comparative Sequencing Program, Pavel P. Khil, John P. Dekker   +6 more
doaj   +1 more source

V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission

eLife, 2021
Membrane fission, the division of a membrane-bound structure into two discrete compartments, is essential for diverse cellular events, such as endocytosis and vesicle/granule biogenesis; however, the process remains unclear.
Yasuo Yamazaki, Yuka Eura, Koichi Kokame
doaj   +1 more source

Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats

Arthritis Research & Therapy, 2022
Background Light alteration affects the internal environment and metabolic homeostasis of the body through circadian rhythm disorders (CRD). CRD is one of the factors that induce and accelerate osteoarthritis (OA). Therefore, the aim of this study was to
Xiaopeng Song, Mingchao Zhao, Jilang Tang, Tianwen Ma, Hui Bai, Xinyu Wang, Lin Liu, Ting Li, Xinyu Xu, Xuanbo Sheng, Binger Zhao, Yingying Wang, Tiantian Wang, Yingchao Guo, Xinmin Zhang, Li Gao   +15 more
doaj   +1 more source

Comparative Genomic Analysis of Antimicrobial-Resistant Escherichia coli from South American Camelids in Central Germany

Microorganisms, 2022
South American camelids (SAC) are increasingly kept in Europe in close contact with humans and other livestock species and can potentially contribute to transmission chains of epizootic, zoonotic and antimicrobial-resistant (AMR) agents from and to ...
Belén González-Santamarina, Michael Weber, Christian Menge, Christian Berens   +3 more
doaj   +1 more source