Results 181 to 190 of about 455,752 (296)

SPARC: a structural pathogenicity algorithm for risk classification of hERG variants. [PDF]

Europace
Chatelain FC, de Oliveira BR, Grataloup G, Robert N, Alameh M, Thollet A, Montnach J, Feliciangeli S, Rio A, Bibault F, Bichet D, Bignucolo O, Extramiana F, Majumder R, Schott JJ, Probst V, Denjoy I, Lesage F, Loussouarn G, De Waard M.   +19 more
europepmc   +1 more source

A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis

Advanced Healthcare Materials, EarlyView.
The Synovium‐on‐Chip comprises a thin microporous PDMS membrane to support co‐culture of fibroblast‐like synoviocytes (FLS), THP‐1‐derived macrophages, and endothelial cells, enabling real‐time analysis of synovial‐vascular interactions. FLS migration through the pores drives endothelial remodeling, while TNF‐α stimulation induces robust inflammatory ...
Laurens R. Spoelstra, Fleur R. Semmekrot, Nuno Araújo‐Gomes, Daniël Wijnperle, Monique M. A. Helsen, Martijn H.J. Van Den Bosch, Loes. I. Segerink, Séverine Le Gac, Marcel Karperien   +8 more
wiley   +1 more source

Horizon: CNV interpretation through rapid automated ACMG-aligned pathogenicity analysis. [PDF]

Hum Genet
Eldesouky M, Shiyas S, Islam A, Hasan MN, Hossain MT, Akter H, Saiful M, Berdiev BK, Kuebler WM, Rahman P, Woodbury-Smith M, Hasan SM, Uddin M, Nassir N.   +13 more
europepmc   +1 more source

Medical Fabrics with Non‐Antibiotic, Supramolecular Antimicrobial Coatings: A Preventive Approach to Combat Biofilm Formation and Bacterial Dissemination

Advanced Healthcare Materials, EarlyView.
The study presents an antibiotic‐free strategy using medical fabrics coated with supramolecular assemblies of polyarginine and hyaluronic acid. These coatings showed strong antimicrobial and anti‐biofilm activity in vitro and in vivo, achieving major bacterial load reductions, including against MRSA.
Adjara Diarrassouba, Abdessalem Rekiki, Cécile Loubière, Sabine Kuchler‐Bopp, Lauriane Petit, Cynthia Calligaro, Derry Mercer, Aurore Gaudin, Naomi Canourgues, Emilie Adicéam, Benoit Beitz, Jeremy Welsch, Annabelle Vigué, Markus j. Kettel, Michael Karl, Chloé Guilbaud‐Chéreau, Philippe Lavalle, Nihal Engin Vrana, Skander Hathroubi   +18 more
wiley   +1 more source

Identification and Management of a Novel Brown Spot Disease in Plums (<i>Prunus salicina</i> Lindl.). [PDF]

Plants (Basel)
Luo Y, Yang Y, Huang L, Liu C, Du X, Guo L, Ma H, Long M, Li S, Wang S, Sun X, Ma G.   +11 more
europepmc   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Refinement of the classification of DDX41 variants through analysis of aggregated clinical datasets. [PDF]

Leukemia
Tiong IS, Hunter S, Kankanige Y, Mehta NN, Chisholm RA, Wu S, Li J, Casan J, Chan KL, Godley LA, Fox LC, Blombery P.   +11 more
europepmc   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

The pathogenicity and future treatment strategies of <i>Candida albicans</i>. [PDF]

Front Cell Infect Microbiol
Wu J, Jiang C, Wang H, Chen T, Chen X, Da W.   +5 more
europepmc   +1 more source

Pathogenicity Underestimated [PDF]

Deutsches Ärzteblatt international, 2015
openaire   +2 more sources