Results 31 to 40 of about 455,752 (296)

An interspecies regulatory network inferred from simultaneous RNA-seq of Candida albicans invading innate immune cells

Frontiers in Microbiology, 2012
The ability to adapt to diverse micro-environmental challenges encountered within a host is of pivotal importance to the opportunistic fungal pathogen C. albicans. We have quantified C.albicans and M. musculus gene expression dynamics during phagocytosis
Lanay eTierney, Jörg eLinde, Sebastian eMüller, Sascha eBrunke, Sascha eBrunke, Juan Camilo Molina, Bernhard eHube, Bernhard eHube, Ulrike eSchöck, Reinhard eGuthke, Karl eKuchler   +10 more
doaj   +1 more source

Antibiotics as a Stressing Factor Triggering the Harboring of Helicobacter pylori J99 within Candida albicans ATCC10231

Pathogens, 2021
First-line treatment for Helicobacter pylori includes amoxicillin and clarithromycin or metronidazole plus a proton pump inhibitor. Treatment failure is associated with antibiotic resistance and possibly also with internalization of H.
Kimberly Sánchez-Alonzo, Libnny Belmar, Cristian Parra-Sepúlveda, Humberto Bernasconi, Víctor L. Campos, Carlos T. Smith, Katia Sáez, Apolinaria García-Cancino   +7 more
doaj   +1 more source

In vitro and in vivo screening for novel essential cell-envelope proteins in Pseudomonas aeruginosa [PDF]

, 2015
The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required.
Bragonzi, Alessandra, Fernandez Pinar, Regina, Imperi, Francesco, LO SCIUTO, Alessandra, Ranucci, Serena, Rossi, Alice   +5 more
core   +1 more source

Chemical Characterization and Leishmanicidal Activity In Vitro and In Silico of Natural Products Obtained from Leaves of Vernonanthura brasiliana (L.) H. Rob (Asteraceae)

Metabolites, 2023
Vernonanthura brasiliana (L.) H. Rob is a medicinal plant used for the treatment of several infections. This study aimed to evaluate the antileishmanial activity of V. brasiliana leaves using in vitro and in silico approaches. The chemical composition of
Yuri Nascimento Fróes, João Guilherme Nantes Araújo, Joyce Resende dos Santos Gonçalves, Milena de Jesus Marinho Garcia de Oliveira, Gustavo Oliveira Everton, Victor Elias Mouchrek Filho, Maria Raimunda Chagas Silva, Luís Douglas Miranda Silva, Lucilene Amorim Silva, Lídio Gonçalves Lima Neto, Renata Mondêgo de Oliveira, Mylena Andréa Oliveira Torres, Luís Cláudio Nascimento da Silva, Alberto Jorge Oliveira Lopes, Amanda Silva dos Santos Aliança, Cláudia Quintino da Rocha, Joicy Cortez de Sá Sousa   +16 more
doaj   +1 more source

The Dual Function of the Fungal Toxin Candidalysin during Candida albicans—Macrophage Interaction and Virulence

Toxins, 2020
The dimorphic fungus Candida albicans is both a harmless commensal organism on mucosal surfaces and an opportunistic pathogen. Under certain predisposing conditions, the fungus can overgrow the mucosal microbiome and cause both superficial and life ...
Annika König, Bernhard Hube, Lydia Kasper   +2 more
doaj   +1 more source

Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria

Computational and Structural Biotechnology Journal, 2021
Many fungi can cause deadly diseases in humans, and nearly every human will suffer from some kind of fungal infection in their lives. Only few antifungals are available, and some of these fail to treat intrinsically resistant species and the ever ...
Raghav Vij, Bernhard Hube, Sascha Brunke
doaj   +1 more source

Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity

Nature Communications, 2022
Commensal bacteria such as Lactobacillus rhamnosus can inhibit the pathogenicity of the fungus Candida albicans. Here, Alonso-Roman et al. investigate the interplay between C. albicans, L.
Raquel Alonso-Roman, Antonia Last, Mohammad H. Mirhakkak, Jakob L. Sprague, Lars Möller, Peter Großmann, Katja Graf, Rena Gratz, Selene Mogavero, Slavena Vylkova, Gianni Panagiotou, Sascha Schäuble, Bernhard Hube, Mark S. Gresnigt   +13 more
doaj   +1 more source

Phage inducible islands in the gram-positive cocci [PDF]

, 2016
The SaPIs are a cohesive subfamily of extremely common phage-inducible chromosomal islands (PICIs) that reside quiescently at specific att sites in the staphylococcal chromosome and are induced by helper phages to excise and replicate.
A Bolotin, A Chopin, A Ruzin, B Frígols, BA Duerkop, C Ubeda, C Ubeda, C Ubeda, C Ubeda, C Ubeda, CH O'Callaghan, CM Hamilton, D Straume, D Viana, Davida Smyth, E Charpentier, E Maiques, G Ram, G Ram, Geeta Ram, IT Paulsen, J Chen, J Chen, J Chen, J Scott, J Scott, J-P Claverys, JA Lindsay, John Chen, José R Penadés, JR Penadés, M Kanehisa, MA Tormo, MD Ferrer, Miguel Martí, MÁ Tormo-Más, MÁ Tormo-Más, N Carpena, N Quiles-Puchalt, N Quiles-Puchalt, Nuria Quiles-Puchalt, RC Matos, Richard P Novick, Roser Martínez-Rubio, RP Novick, RP Novick, Suzanne Humphrey, SV Nguyen   +47 more
core   +1 more source

Clinical performance of two commercial PCR assays for the detection of macrolide resistance in Mycoplasma pneumoniae

Journal of Clinical Microbiology
Macrolides are the first-line treatment for Mycoplasma pneumoniae infections; however, macrolide resistance has been reported. We evaluated the clinical performance of two commercial assays for detecting macrolide-resistant M.
Nadège Hénin, Alicia Silvant, Marie Gardette, Carla Balcon, Jennifer Guiraud, Cécile Bébéar, Sabine Pereyre   +6 more
doaj   +1 more source

DNA methylation profiling to assess pathogenicity of BRCA1 unclassified variants in breast cancer [PDF]

, 2015
Germline pathogenic mutations in BRCA1 increase risk of developing breast cancer. Screening for mutations in BRCA1 frequently identifies sequence variants of unknown pathogenicity and recent work has aimed to develop methods for determining pathogenicity.
AFFECT, Brown, R, El-Bahrawy, M, Flanagan, JM, Flower, KJ, Goldgar, DE, KConFab, Morris, JR, Parsons, MT, Shenker, NS, Spurdle, AB   +10 more
core   +1 more source