Results 61 to 70 of about 3,834,924 (331)
No ...
Pellegrino, Valeria +5 more
+10 more sources
Comparative pathology of experimental pulmonary tuberculosis in animal models
Research in human tuberculosis (TB) is limited by the availability of human tissues from patients, which is often altered by therapy and treatment. Thus, the use of animal models is a key tool in increasing our understanding of the pathogenesis, disease ...
Laura Hunter +7 more
doaj +1 more source
A Review on the Applications of Crowdsourcing in Human Pathology
The advent of the digital pathology has introduced new avenues of diagnostic medicine. Among them, crowdsourcing has attracted researchers' attention in the recent years, allowing them to engage thousands of untrained individuals in research and ...
Alialy, Roshanak +6 more
core +2 more sources
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Prostate biopsy: is age important for determining the pathological features in prostate cancer?
INTRODUCTION: The influence of age on the aggressiveness of prostate cancer (PCa) is controversial. This study aims to assess the influence of age in determining the pathological features of biopsies from patients diagnosed with PCa. PATIENTS AND METHODS:
Alberto A. Antunes +5 more
doaj +1 more source
Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window? [PDF]
LARGE is a glycosyltransferase involved in glycosylation of α-dystroglycan (α-DG). Absence of this protein in the LARGEmyd mouse results in α-DG hypoglycosylation, and is associated with central nervous system abnormalities and progressive muscular ...
A Brancaccio +54 more
core +4 more sources
CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease [PDF]
Nicolas R. Barthélemy +18 more
openalex +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Impact of COVID-19 Pandemic on Pathology Residency Program: An Experience from India
Objective: To study the impact of the COVID-19 pandemic on pathology residents through a questionnaire-based survey. Material and Method: We designed a Google survey questionnaire with 20-questions and distributed it to the pathology residents across ...
Arti KHATRI +5 more
doaj +1 more source

