Results 61 to 70 of about 1,215,739 (337)

Low Renalase Levels in Newly Diagnosed CML: Dysregulation Sensitive to Modulation by Tyrosine Kinase Inhibitors

Pathophysiology
Background: A dysregulated proinflammatory microenvironment is considered one of the reasons why current therapies of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKI) do not secure disease control.
Jelena Milenkovic, Dijana Stojanovic, Sanja Velickovic, Branka Djordjevic, Goran Marjanovic, Maja Milojkovic   +5 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Flavonoid-Mediated Suppression of Tumor Angiogenesis: Roles of Ang-Tie/PI3K/AKT

Pathophysiology
Angiogenesis is a process involved in the formation of new blood capillaries from pre-existing ones. It is regulated by several anti-angiogenic molecules involved in tumor growth and metastasis.
Shallu Saini, Hardeep Singh Tuli, Reena V. Saini, Adesh K. Saini, Katrin Sak, Damandeep Kaur, Moyad Shahwan, Ritu Chauhan, Abhishek Chauhan   +8 more
doaj   +1 more source

The Pathophysiology Gastroesophageal Reflux Disease [PDF]

, 2007
The incidence of Gastroesophageal Reflux Disease (GERD), especially in Indonesia, is increasing with the change of community life-style. Also, the doctors\u27 perception in understanding clinical manifestation of GERD is alike in addition to the ...
Simadibrata, M. (Marcellus), Syam, A. F. (Ari), Waleleng, B. J. (Bradley)   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

IGFBP-2 in Critical Illness: A Prognostic Marker in the Growth Hormone/Insulin-like Growth Factor Axis

Pathophysiology
Critical illness (CI) triggers complex disruptions in the growth hormone (GH)/insulin-like growth factor (IGF) axis, significantly affecting the dynamics of insulin-like growth-factor-binding proteins (IGFBPs).
Christos Savvidis, Eleni Kouroglou, Efthymia Kallistrou, Dimitra Ragia, Sofia Dionysopoulou, Georgios Gavriiloglou, Vasiliki Tsiama, Stella Proikaki, Konstantinos Belis, Ioannis Ilias   +9 more
doaj   +1 more source

Methamphetamine and Designer Stimulants Modulate Tonic Human Cerebrovascular Smooth Muscle Contractility: Relevance to Drug-Induced Neurovascular Stress

Pathophysiology, 2023
To avoid criminal prosecution, clandestine chemists produce designer stimulants that mimic the pharmacological and psychoactive effects of conventional stimulants, such as methamphetamine.
Nicole Hall, Nhi Dao, Cameron Hewett, Sara Oberle, Andrew Minagar, Kariann Lamon, Carey Ford, Bruce E. Blough, J. Steven Alexander, Kevin S. Murnane   +9 more
doaj   +1 more source

Budesonide Reverses Lung Hyperinflation in Childhood Asthma: a Controlled Study [PDF]

, 1999
Budesonide (800 mg bid, for 2 months) was administered to 12 asthmatic children (mean age, 11.293.3 years) with lung hyperinflation (TGV]130% predicted and:or RV]140% predicted) in a randomised, placebo controlled, double blind, crossover study.
Gamboa, T, Neuparth, N, Pereira, C, Rendas, A, Rosado-Pinto, J   +4 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Acetabular Wall Weakening in Total Hip Arthroplasty: A Pilot Study

Pathophysiology, 2023
Total hip arthroplasty is a widely performed operation allowing disabled patients to improve their quality of life to a degree greater than any other elective procedure.
Madeline Gautreaux, Steven Kautz, Zashiana Martin, Edward Morgan, R. Shane Barton, Matthew Dubose, Hayden McBride, Giovanni F. Solitro   +7 more
doaj   +1 more source