Results 41 to 50 of about 309,661 (267)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Representative dissimilar path queries: accommodating human movement dynamics in road networks
Journal of Spatial Information Science, 2023 We introduce a representative dissimilar path (RDP) query, a novel type of path query in road networks. The k representative paths (RPs) between a source and a destination locations have k smallest costs for a feature (e.g., length, number of road ...
Tanzima Hashem +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
[r,s,t]-colourings of paths [PDF]
Opuscula Mathematica, 2007 The concept of \([r,s,t]\)-colourings was recently introduced by Hackmann, Kemnitz and Marangio [A. Kemnitz, M. Marangio, \([r,s,t]\)-Colorings of Graphs, Discrete Math., to appear] as follows: Given non-negative integers \(r\), \(s\) and \(t\), an \([r ...
Marta Salvador Villà, Ingo Schiermeyer
doaj
Real Analysis Exchange, 2004 If \(E\) is a system of paths, then the function \(f\) is \(E\)-continuous at \(x\) if there exists a path \(A\in E(x)\) such that \(f\) restricted to \(A\) is continuous at \(x\). A function \(f\) is called \(E\)-continuous if it is \(E\)-continuous at each \(x\).
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
La performance del sistema educativo argentino en las últimas décadas
Análisis, 2017 In the context of expansion and multiple transformations of the Argentine educational system, overfly discussions on institutional expansion, the evolution of the school population and samples of a system designed to generate greater inclusion. The aim of
Analía Otero, Agustina Córica
doaj +1 more source