Results 41 to 50 of about 2,163,430 (288)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The need for a Canadian Criminal Code offence of coercive control
Journal of Community Safety and Well-BeingCanada is currently considering legislating an offence of coercive control. Coercive controlling behaviour is currently criminalized in the UK, Scotland, Ireland, Northern Ireland and New South Wales, Australia.
Crystal J Giesbrecht
doaj +1 more source
L’évaluation des réseaux de circulation en géographie quantitative
Les Nouvelles de l’Archéologie, 2009 Circulation networks are often implied in spatial phenomena, since they highlight displacements or relationships of places on territories. To analyse such phenomena, specifics tools are needed, in particular indicators coming from quantitative geography.
Jean-François Gleyze
doaj +1 more source
, 2009 Optimal paths play a fundamental role in numerous physical applications ranging from random polymers to brittle fracture, from the flow through porous media to information propagation.
Andrade Jr, J. S. +3 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Monitoring the impact of COVID-19 in France on cancer care: a differentiated impact
Scientific Reports, 2022 The COVID-19 pandemic has had a substantial and lasting impact on care provision, particularly in the field of cancer care. National steering has helped monitor the health situation and adapt the provision and organisation of care. Based on data from the
Christine Le Bihan Benjamin +7 more
doaj +1 more source
Bi-banded Paths, a Bijection and the Narayana Numbers [PDF]
, 2010 We find a bijection between bi-banded paths and peak-counting paths, applying to two classes of lattice paths including Dyck paths. Thus we find a new interpretation of Narayana numbers as coefficients of weight polynomials enumerating bi-banded Dyck ...
Osborn, Judy-anne
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Seeded PageRank Solution Paths
, 2015 We study the behavior of network diffusions based on the PageRank random walk from a set of seed nodes. These diffusions are known to reveal small, localized clusters (or communities) and also large macro-scale clusters by varying a parameter that has a ...
Gleich, David F., Kloster, Kyle
core +1 more source