Results 51 to 60 of about 309,661 (267)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Crossing Numbers of Join Products of All 5-Vertex Graphs with Discrete Graphs, Paths and Cycles

open access: yesMathematics
This paper investigates crossing numbers of join products involving all non-isomorphic graphs of order five and the graph families Dn, Pn, and Cn. By systematically examining all 34 graphs of order five, we establish a unified classification of 102 ...
Jana Fortes, Mária Timková
doaj   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

open access: yes
Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Induced Subgraph Saturated Graphs

open access: yesTheory and Applications of Graphs, 2016
A graph $G$ is said to be \emph{$H$-saturated} if $G$ contains no subgraph isomorphic to $H$ but the addition of any edge between non-adjacent vertices in $G$ creates one.
Craig Tennenhouse
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Humans and Tits in the City: Quantifying the Effects of Human Presence on Great Tit and Blue Tit Reproductive Trait Variation

open access: yesFrontiers in Ecology and Evolution, 2017
Environmental conditions are key drivers of life-history evolution, and the urban environment is an extreme form of land-use readily inhabited by avian wildlife, whose life-history variation in such altered environment is still poorly understood ...
Michela Corsini   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Sabato's spiritual crisis: The way from science to literature [PDF]

open access: yesSinteze, 2017
The paper is entirely dedicated to the period of spiritual crisis in the life of Argentine writer Ernesto Sabato. In the introduction are stated basic biographical details from the life of the writer for the purpose of further elaboration of specific ...
Čanović Ana R.
doaj  

Finding Vanished Routes: Applying a Multi-modelling Approach on Lost Route and Path Networks in the Veluwe Region, the Netherlands

open access: yesRural Landscapes: Society Environment History, 2018
Route networks are influenced by cultural and environmental dynamics. Consequently, route networks themselves often are dynamic as well. This is especially true in lowland areas, such as the Netherlands, where environmental processes (e.g ...
Willem F. Vletter, Rowin J. van Lanen
doaj   +1 more source

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