Results 71 to 80 of about 2,455,447 (352)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
jimmynewland/paths-up-expeditions-in-computing-ret2018: PATHS-UP/Expeditions in Computing RET 2018
, 2020 PATHS-UP and Expeditions in Computing RET 2018 This python code is part of the Rice University PATHS-UP/Expeditions in Computing RET. Two separate data acquisition channels are available.
Jimmy Newland
core +1 more source
Monitoring the impact of COVID-19 in France on cancer care: a differentiated impact
Scientific Reports, 2022 The COVID-19 pandemic has had a substantial and lasting impact on care provision, particularly in the field of cancer care. National steering has helped monitor the health situation and adapt the provision and organisation of care. Based on data from the
Christine Le Bihan Benjamin +7 more
doaj +1 more source
Real Analysis Exchange, 2004 If \(E\) is a system of paths, then the function \(f\) is \(E\)-continuous at \(x\) if there exists a path \(A\in E(x)\) such that \(f\) restricted to \(A\) is continuous at \(x\). A function \(f\) is called \(E\)-continuous if it is \(E\)-continuous at each \(x\).
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Representative dissimilar path queries: accommodating human movement dynamics in road networks
Journal of Spatial Information Science, 2023 We introduce a representative dissimilar path (RDP) query, a novel type of path query in road networks. The k representative paths (RPs) between a source and a destination locations have k smallest costs for a feature (e.g., length, number of road ...
Tanzima Hashem +3 more
doaj +1 more source
, 1991 We report calculations of electron inelastic mean free paths (IMFPs) of 50–2000 eV electrons for a group of 14 organic compounds: 26-n-paraffin, adenine, β-carotene, bovine plasma albumin, deoxyribonucleic acid, diphenylhexatriene, guanine, kapton ...
S. Tanuma, C. Powell, D. Penn
semanticscholar +1 more source