Results 61 to 70 of about 116,736 (298)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
The spectral radius of graphs without paths and cycles of specified length [PDF]
, 2009 Let G be a graph with n vertices and μ ( G ) be the largest eigenvalue of the adjacency matrix of G . We study how large μ ( G ) can be when G does not contain cycles and paths of specified order.
V. Nikiforov
semanticscholar +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Edge ideals and DG algebra resolutions
Le Matematiche, 2015 Let R = S/I where S = k[T_1, . . . , T_n] and I is a homogeneous ideal in S. The acyclic closure R<Y> of k over R is a DG algebra resolution obtained by means of Tate’s process of adjoining variables to kill cycles.
Adam Boocher +4 more
doaj
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Γ-independent dominating graphs of paths and cycles [PDF]
Songklanakarin Journal of Science and Technology (SJST)A set D of vertices in a graph G is an independent dominating set if D is a set of pairwise nonadjacent vertices of G such that every vertex of G not in D is adjacent to at least one vertex in D.
Roongrat Samanmoo +1 more
doaj
Simple Paths and Cycles of Directed Graph for Stock Trading Network Based on STP
Journal of Mathematics, 2022 The stock trading relationship of buyers and sellers in the stock market can be characterized by a directed graph. It is an important way to study stock trading network through simple directed paths and cycles.
Xiaolong Liu, Li Ma
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 To disclose the net effect of light on microalgal growth in photobioreactors, self-shading and mixing-induced light–dark cycles must be minimized and discerned from the transient phenomena of acclimation.
Alberto Saccardo +3 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source