Results 61 to 70 of about 449,698 (268)

Adverse outcome pathways and ecological risk assessment: Bridging to population-level effects

Environmental Toxicology and Chemistry, 2011
Abstract Maintaining the viability of populations of plants and animals is a key focus for environmental regulation. Population-level responses integrate the cumulative effects of chemical stressors on individuals as those individuals interact with and are affected by their conspecifics, competitors, predators, prey, habitat, and other ...
KRAMER, VINCENT J., ETTERSON, MATTHEW A., HECKER, MARKUS, MURPHY, CHERYL A., ROESIJADI, GURITNO, SPADE, DANIEL J., SPROMBERG, JULANN A., WANG, MAGNUS, ANKLEY, GERALD T.   +8 more
openaire   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Commodity risk assessment of Hamamelis mollis plants from the UK

EFSA Journal
The European Commission requested the EFSA Panel on Plant Health to prepare and deliver risk assessments for commodities listed in Commission Implementing Regulation (EU) 2018/2019 as ‘High risk plants, plant products and other objects’.
EFSA Panel on Plant Health (PLH), Antonio Vicent Civera, Paula Baptista, Anna Berlin, Elisavet Chatzivassiliou, Jaime Cubero, Nik Cunniffe, Eduardo de laPeña, Nicolas Desneux, Francesco Di Serio, Anna Filipiak, Paolo Gonthier, Beata Hasiów‐Jaroszewska, Hervé Jactel, Blanca B. Landa, Lara Maistrello, David Makowski, Panagiotis Milonas, Nikos T. Papadopoulos, Hanna Susi, Dirk Jan van derGaag, Jane Debode, Juan A. Navas‐Cortes, Christos Kritikos, Maria Kormpi, Dimitrios Papachristos, Chrysavgi Reppa, Antigoni Akrivou, Spyridon Antonatos, Despoina Beris, Olaf Mosbach Schulz, Monia Federica Lombardo, Ciro Gardi, Roel Potting   +33 more
doaj   +1 more source

Human Health Risk Assessment of Chlorinated Hydrocarbons in Groundwater Based on Multi-Pathway Analysis

Toxics
The rapid development of the global chemical industry has led to widespread groundwater contamination, with frequent pollution incidents posing severe threats to water safety.
Yidi Wang, Guilan Li, Xiaohan Li, Ye Yang, Kaifang Ding, Shilu Xing, Yilong Zhang, Luxing Zhang   +7 more
doaj   +1 more source

Grouping of endocrine disrupting chemicals for mixture risk assessment – Evidence from a rat study

Environment International, 2020
Exposure to mixtures of endocrine disrupting chemicals may contribute to the rising incidence of hormone-related diseases in humans. Real-life mixtures are complex, comprised of chemicals with mixed modes of action, and essential knowledge is often ...
Sofie Christiansen, Marta Axelstad, Martin Scholze, Hanna K.L. Johansson, Ulla Hass, Karen Mandrup, Henrik Lauritz Frandsen, Hanne Frederiksen, Louise Krag Isling, Julie Boberg   +9 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Development of a breast cancer risk assessment and primary prevention pathway for women aged 30-39 years: Views of UK primary care providers on the role of primary care.

PLoS ONE
BackgroundIdentifying women aged 30-39 years at increased risk of developing breast cancer would allow them to receive screening and prevention offers. For this to be feasible, the practicalities of organising risk assessment and primary prevention must ...
Sarah Hindmarch, Louise Gorman, Juliet A Usher-Smith, Victoria G Woof, Sacha J Howell, David P French   +5 more
doaj   +1 more source

Construction of an adverse outcome pathway framework for arsenic-induced lung cancer using a network-based approach

Ecotoxicology and Environmental Safety
Environmental pollutants are considered as a cause of tumorigenesis, but approaches to assess their risk of causing tumors remain insufficient. As an alternative approach, the adverse outcome pathway (AOP) framework is used to assess the risk of tumors ...
Cheng Cheng, Bowen Fan, Yi Yang, Peiwen Wang, Meng Wu, Haibo Xia, Binafsha Manzoor Syed, Hao Wu, Qizhan Liu   +8 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source