Results 181 to 190 of about 38,270 (217)

Deciphering spatial heterogeneity of patient-derived organoids of colorectal tumors for drug discovery

Norkin M, Bac J, McConnell L, Cisarovsky C, Alexandre-Gaveta M, Andre S, Tanaka S, Digklia A, Hoehnel S, Tissot S, Huelsken J, Rapsomaniki M, Gottardo R, Homicsko K.   +13 more
europepmc   +1 more source

The irreplaceable role of pathology for the clinical translation of patient-derived organoids in precision medicine. [PDF]

Precis Clin Med
Liang Z, Yang P, Zhu X, Liu Y, Shao M, Yang Z, Bao J.   +6 more
europepmc   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Patient-derived organoids as a model to study tubo-ovarian carcinoma: a pathologist's perspective. [PDF]

J Ovarian Res
Alves-Vale C, Galvão B, Silvestre AR, Pereira JS, Bei L, Fernandes JP, Borralho P, Carmo-Fonseca M, Custódio N.   +8 more
europepmc   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Patient-derived organoids and neurospheres recapitulate salient features of primary tumor heterogeneity. [PDF]

Neurooncol Adv
Moore Z, Storey C, Brown DV, Valkovic A, Spiteri M, Pignatelli JF, Oliver SJ, Fakhri A, Drummond KJ, Hart J, Harris L, Malinowski S, Ligon KL, Sieber OM, Whittle JR, Freytag S, Best SA.   +16 more
europepmc   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Genomic fidelity and evolution of cancer patient-derived organoids

Raz L, Khoury H, Ben-Yishay T, Saad R, Zoabi A, Orlandi G, Donzelli S, Blandino G, Ben-David U.   +8 more
europepmc   +1 more source

Advances in precision oncology using patient-derived organoids and functional biomaterials. [PDF]

Front Cell Dev Biol
Singh H, Mijakovic I, Singh P.
europepmc   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source