Results 271 to 280 of about 51,351 (304)

Establishment and characterization of meningioma patient-derived organoid

Journal of Clinical Neuroscience, 2021
Meningioma is a central nervous system tumor originated from arachnoid cells. 2D cell culture is widely used as a platform for tumor research as it enables us to culture cells in in vitro and a controlled environment. However, in 2D culture condition, 3D architecture of in vivo tumor mass is lost and phenotypic change may occur. Due to the drawbacks of
Henry Siu Cheung, Chan, Ho Keung, Ng, Aden Ka-Yin, Chan, Sau Ha, Cheng, Chit, Chow, Nathalie, Wong, George Kwok Chu, Wong   +6 more
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Establishment and Culture of Patient-Derived Breast Organoids

Journal of Visualized Experiments, 2023
Breast cancer is a complex disease that has been classified into several different histological and molecular subtypes. Patient-derived breast tumor organoids developed in our laboratory consist of a mix of multiple tumor-derived cell populations, and thus represent a better approximation of tumor cell diversity and milieu than the established 2D ...
Disha, Aggarwal, Suzanne, Russo, Payal, Naik, Sonam, Bhatia, David L, Spector   +4 more
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Immunofluorescence staining of colorectal cancer patient-derived organoids

2022
Organoids recapitulate the cellular heterogeneity, functionality, architecture and molecular signature of the organ or diseased tissue from which they are derived. They thus provide a bridge between traditional 2D culture systems and animal models and have profoundly enhanced our ability to study organ development and disease in vitro.
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Organoid culture system for patient-derived lung metastatic osteosarcoma

Medical Oncology, 2020
Osteosarcoma (OS) is the most common primary bone malignancy with high rates of recurrence and metastasis. OS often spreads to lungs, an optimized model for studying lung metastatic OS cells may help develop potential therapies for patients with lung metastasis. Here we firstly report an organoid culture system for lung metastatic OS tissues.
Aina He, Yujing Huang, Wanying Cheng, Deng Zhang, Weiwei He, Yueqing Bai, Chao Gu, Zhongping Ma, Zhenfang He, Guifan Si, Bing Chen, David T. Breault, Min Dong, Dongxi Xiang   +13 more
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Patient-derived organoids as a model for tumor research

2022
Cancer represents a leading cause of death, despite the rapid progress of cancer research, leading to urgent need for accurate preclinical model to further study of tumor mechanism and accelerate translational applications. Cancer cell lines cannot fully recapitulate tumors of different patients due to the lack of tumor complexity and specification ...
Jia, Wang, Xiaoying, Feng, Zhichao, Li, Yongsong, Chen, Weiren, Huang   +4 more
openaire   +2 more sources

Establishment of Patient-derived Cholangiocarcinoma Organoids

European Journal of Surgical Oncology, 2023
Huisong Lee, Hyeon Kook Lee, Ja Lok Ku
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Patient-derived Organoids in Bladder Cancer: Opportunities and Challenges

European Urology Focus
Background And Objective Bladder cancer (BLCa) remains a prevalent malignancy with high recurrence rates and limited treatment options. In recent years, patient-derived organoids (PDOs) have emerged as a promising platform for studying cancer biology and therapeutic responses in a personalized manner.
Martina, Radić, Martin, Egger, Marianna, Kruithof-de Julio, Roland, Seiler   +3 more
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Patient‐derived organoid model of olfactory ensheathing cell tumor

International Forum of Allergy & Rhinology
Key points We developed a culture model of a human olfactory ensheathing cell tumor. Cultured organoids resemble normal ensheathing cells. Assays suggest that this model provides a tool for studying the roles of these glial cells in the maintenance of the peripheral olfactory system.
John B. Finlay, Ralph Abi Hachem, Patrick Codd, Bradley J. Goldstein   +3 more
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Patient-derived colorectal organoids for microfluidics applications

European Journal of Surgical Oncology, 2021
M. Ibrahim Khot, Masahiro Inoue, Nikil Kapur, David G. Jayne   +3 more
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Personalized Care for Pancreatic Cancer: Harnessing Patient-Derived Organoids

Journal of Gastrointestinal Cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers. Surgical resection combined with appropriate chemotherapy currently offers the best chance for long-term survival and potential cure. However, effective treatment is hindered by the limited chemotherapy options and the absence of reliable clinical tools to guide chemotherapy ...
L, Demyan, M J, Weiss
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