Results 61 to 70 of about 51,351 (304)

Low-viscosity Matrix Suspension Culture for Human Colorectal Epithelial Organoids and Tumoroids

Bio-Protocol, 2022
Three-dimensional culture of human normal colorectal epithelium and cancer tissue as organoids and tumoroids has transformed the study of diseases of the large intestine.
Tao Tan, Yumiko Hirokawa, Jordan Clarke, Anuratha Sakthianandeswaren, Oliver Sieber   +4 more
doaj   +1 more source

Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. [PDF]

, 2019
Fluidity in cell fate or heterogeneity in cell identity is an interesting cell biological phenomenon, which at the same time poses a significant obstacle for cancer therapy.
Doh, Hanna, Kessenbrock, Kai, Roose, Jeroen P, Samocha, Alexandr   +3 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment

Frontiers in Oncology, 2020
New tools are needed to match cancer patients with effective treatments. Patient-derived organoids offer a high-throughput platform to personalize treatments and discover novel therapies.
Joe T. Sharick, Joe T. Sharick, Christine M. Walsh, Carley M. Sprackling, Cheri A. Pasch, Dan L. Pham, Dan L. Pham, Karla Esbona, Alka Choudhary, Alka Choudhary, Rebeca Garcia-Valera, Rebeca Garcia-Valera, Rebeca Garcia-Valera, Mark E. Burkard, Mark E. Burkard, Stephanie M. McGregor, Stephanie M. McGregor, Kristina A. Matkowskyj, Kristina A. Matkowskyj, Kristina A. Matkowskyj, Alexander A. Parikh, Ingrid M. Meszoely, Mark C. Kelley, Susan Tsai, Dustin A. Deming, Dustin A. Deming, Dustin A. Deming, Melissa C. Skala, Melissa C. Skala, Melissa C. Skala   +29 more
doaj   +1 more source

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. [PDF]

, 2019
Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences of these mutations and whether they confer gain or loss of function is unknown1-9. Here, by annotating the landscape of FOXA1 mutations
Adams, Elizabeth J, Barbieri, Christopher E, Bose, Rohit, Chhangawala, Sagar, Cho, Hyunwoo, Davicioni, Elai, DiLoreto, Rose, Gruet, Antoine, Hoover, Elizabeth, Karthaus, Wouter R, Leslie, Christina S, Liu, Deli, Liu, Yang, Sawyers, Charles L, Sboner, Andrea, Watson, Philip A, Zhang, Zeda   +16 more
core   +1 more source

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]

, 2018
Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R, Escusa, Hazel S, Fletterick, Robert J, Ingraham, Holly A, Klein, Ophir D, Moore, David D, Nattiv, Roy, Suzawa, Miyuki, Wang, Hongtao   +8 more
core   +2 more sources

Patient-derived organoids in precision cancer medicine

Med
Organoids are three-dimensional (3D) cultures, normally derived from stem cells, that replicate the complex structure and function of human tissues. They offer a physiologically relevant model to address important questions in cancer research. The generation of patient-derived organoids (PDOs) from various human cancers allows for deeper insights into ...
Le Tong, Weiyingqi Cui, Boya Zhang, Pedro Fonseca, Qian Zhao, Ping Zhang, Beibei Xu, Qisi Zhang, Zhen Li, Brinton Seashore-Ludlow, Ying Yang, Longlong Si, Andreas Lundqvist   +12 more
openaire   +3 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Organoids and organs-on-chips: insights into predicting the efficacy of systemic treatment in colorectal cancer

Cell Death Discovery, 2023
Cancer heterogeneity has posed a great challenge to traditional cancer treatment, with the reappearance of cancer heterogeneity of inter and intra patients being especially critical. Based on this, personalized therapy has emerged as significant research
Jialong Zhu, Linlin Ji, Yitian Chen, Huiyu Li, Mengxi Huang, Zhe Dai, Jing Wang, Dan Xiang, Gongbo Fu, Zengjie Lei, Xiaoyuan Chu   +10 more
doaj   +1 more source

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation [PDF]

, 2016
Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely ...
Alastair J.M. Watson, Arif B. Ekici, Becker, Christoph Becker, Claudia Günther, Cord Brakebusch, Distler, Gionata Fiorino, Heller, Hopkins, Imke Atreya, Kerstin Amann, Lin, Markus F. Neurath, Martin Bergö, Ohkusa, Pastorelli, Pechlivanis, Raja Atreya, Rocío López-Posadas, Silvio Danese, Stefan Tenzer, Stefan Wirtz, Stefania Vetrano, Turcotte, Ulrike Billmeier, Veronika Thonn, Zverina   +27 more
core   +1 more source