Results 91 to 100 of about 1,465,622 (305)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Incorporating development of a patient-reported outcome instrument in a clinical drug development program: examples from a heart failure program. [PDF]

, 2016
BackgroundPatient-reported outcome (PRO) measures can be used to support label claims if they adhere to US Food & Drug Administration guidance. The process of developing a new PRO measure is expensive and time-consuming.
Anatchkova, Milena, Chau, Dina, Malik, Fady I, Oko-Osi, Hafiz, Patrick, Donald L, Spertus, John, Teerlink, John R, von Maltzahn, Robyn, Wiklund, Ingela   +8 more
core   +1 more source

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego, Kellee Parker, William C. Thomsen, James B. Ford, Mallorie B. Heneghan, David Spencer Mangum, Jennifer L. McNeer, Luke D. Maese, Claire E. F. Miller, Richard Lemons, Taumoha Ghosh   +10 more
wiley   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Patient‐reported outcome measures in pediatrics: An overview of reviews

Pediatric Discovery
Patient‐reported outcome measures (PROMs) are standardized and validated self‐administered questionnaires for assessing patients' overall well‐being, disease burden, and health‐related quality of life.
Ruobing Lei, Jin Xiong, Haiyun Wang, Yuehuan Li, Janne Estill, Qiu Li, Yaolong Chen   +6 more
doaj   +1 more source

Patient-Reported Outcome Measures in Inflammatory Bowel Disease

Canadian Journal of Gastroenterology and Hepatology, 2014
Patient-reported outcome measures (PROMs) are increasingly used in both research and clinical health settings. With the recent development of United States Food and Drug Administration guidance on PROMs, more attention is being devoted to their role and ...
Wael El-Matary
doaj   +1 more source

Patient-reported outcome measures in orthopaedics

Danish Medical Journal
INTRODUCTION. The Patient Activity Treatment Outcome Scale (PATOS) is a novel patient-reported outcome measure (PROM). This study explored patients’ and orthopaedic surgeons’ experiences with PATOS as part of a PROM battery. It aimed to investigate its influence on patient involvement and healthcare decisions about knee or hip osteoarthritis patients ...
Hansen, Stine Thestrup, Jensen, Rasmus Stig, Holm, Henriette Appel, Liljensøe, Anette   +3 more
openaire   +3 more sources

The impact of culturally competent diabetes care interventions for improving diabetes-related outcomes in ethnic minority groups : a systematic review [PDF]

, 2012
Aim  To examine the evidence on culturally competent interventions tailored to the needs of people with diabetes from ethnic minority groups. Methods  MEDLINE (NHS Evidence), CINAHL and reference lists of retrieved papers were searched from inception ...
Cannaby, A. M., Sandhu, Harbinder, Sturt, Jackie, Zeh, Peter   +3 more
core   +1 more source

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source