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Patient-reported outcome measurement [PDF]

Journal of the Royal Society of Medicine, 2010
Alan Maynard and Karen Bloor1 raise interesting questions, particularly in relation to breast cancer. One issue is that treatment-related toxicities may not become problematic for several years, particularly when radiotherapy is administered. Research so far seems to indicate that hypofractionation causes more long-term problems than hyperfractionation,
openaire   +2 more sources

Prognostic Significance of Patient-Reported Outcomes in Cancer.

JCO Oncology Practice, 2020
PURPOSE Performance status (PS), an established prognostic surrogate of cancer survival, is a physician-synthesized metric of patient symptoms and mobility that is prone to bias and subjectivity.
K. Kerrigan, Shiven B. Patel, B. Haaland, D. Ose, Anna Weinberg Chalmers, Tyler Haydell, N. Meropol, W. Akerley   +7 more
semanticscholar   +1 more source

Patient-reported outcome measures [PDF]

Journal of the Royal Society of Medicine, 2007
In their recent essay (JRSM 2007;100:306-8), Maynard & Ayalew referred to the absence of patient reported outcome measures (PROM). They should have been aware that the Royal College of Surgeons of England, with the London School of Hygiene and Tropical Medicine, carried out a project to establish the feasibility of applying PROM for elective surgical ...
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eRAPID electronic patient self-Reporting of Adverse-events: Patient Information and aDvice: a pilot study protocol in pelvic radiotherapy

Pilot and Feasibility Studies, 2018
Background An estimated 17,000 patients are treated annually in the UK with radical radiotherapy (RT) for pelvic cancer. New treatment approaches in RT have increased survivorship and changed the subjective toxicity profile for patients who experience ...
Patricia Holch, Simon Pini, Ann M. Henry, Susan Davidson, Jacki Routledge, Julia Brown, Kate Absolom, Alexandra Gilbert, Kevin Franks, Claire Hulme, Carolyn Morris, Galina Velikova, on behalf of the eRAPID radiotherapy work group   +12 more
doaj   +1 more source

Patient-reported outcome measures for clinical decision-making in outpatient follow-up: validity and reliability of a renal disease questionnaire

Journal of Patient-Reported Outcomes, 2021
Background Patient-reported outcome measures are increasingly used by clinicians to support communication in telephone- or face-to-face consultations with patients.
Birgith Engelst Grove, Liv Marit Valen Schougaard, Per Ramløv Ivarsen, Derek Kyte, Niels Henrik Hjollund, Annette de Thurah   +5 more
doaj   +1 more source

Patient reported outcomes in orthopaedics [PDF]

Journal of Orthopaedic Research, 2017
ABSTRACTPatient reported outcome measures (PROMs) are key tools when performing clinical research and PROM data are increasingly used to inform clinical decision‐making, patient‐centered care, health policy and more recently, reimbursement decisions. PROMs must possess particular properties before they are used. Thus purpose of this paper is to give an
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Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Key considerations for digital decentralised clinical trials from a feasibility study assessing pacing interventions for long COVID

Scientific Reports
Post COVID-19 condition or long COVID is highly prevalent and often debilitating, with key symptoms including fatigue, breathlessness, and brain fog. There is currently a lack of evidence-based treatments for this highly complex syndrome. There is a need
Christel McMullan, Shamil Haroon, Grace Turner, Olalekan Lee Aiyegbusi, Anuradhaa Subramanian, Sarah E. Hughes, Sarah Flanagan, Krishnarajah Nirantharakumar, Elin Haf Davies, Chris Frost, Louise Jackson, Naijie Guan, Yvonne Alder, Amy Chong, Lewis Buckland, Felicity Jeyes, David Stanton, Melanie Calvert   +17 more
doaj   +1 more source

Consistent Patient-Reported Outcomes

Value in Health, 2002
Health-related quality of life (HRQL) measures extend patient outcome assessment beyond survival, adverse effects, and clinical efficacy, and reflect the patient’s perspective on the impact of disease and its treatment on functioning and wellbeing. An important objective for evaluating HRQL outcomes is to demonstrate the value of new pharmaceutical ...
openaire   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source