Results 91 to 100 of about 383,023 (311)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Service User and Carer Involvement in Mental Health Education, Training and Research – A Literature Review

, 2009
As part of an evaluation of service users’ and carers’ experience of involvement in mental health education, training and research, an extended literature review was undertaken. The purpose of this was to review policy underpinning service user and carer
Minogue, Virginia, Ramsay, Trevor, Gelsthorpe, Simon, Firth, Sarah, Holt, Barrie, Karban, Kate   +5 more
core   +1 more source

The patient-reported outcome measure for older people living with frailty receiving acute care (PROM-OPAC): field-testing and validation

Journal of Patient-Reported Outcomes
Background Current acute healthcare service metrics are not meaningful for older people living with frailty. Healthcare knowledge, situational security, and physical and psychosocial function are important outcomes typically not collected.
James D. van Oppen, Simon P. Conroy, Jagruti Lalseta, Nicola Mackintosh, Peter Riley, Vivien Richardson, Jose M. Valderas, Timothy J. Coats   +7 more
doaj   +1 more source

Involving public and patients in research

The Bulletin of the Royal College of Surgeons of England, 2014
What does patient and public involvement (PPI) in research mean? The National Institute for Health Research (NIHR) defines ‘patient and public’ as patients, potential patients, their carers, people who use health and social care services, and organisations that represent people who use these services.
V Kasivisvanathan, Kate Williams
openaire   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Patient and public involvement in primary care groups : a case study [PDF]

, 2007
EThOS - Electronic Theses Online ServiceGBUnited ...
Fee, Verna
core  

Commissioning for long-term conditions: hearing the voice of and engaging users - a qualitative multiple case study [PDF]

, 2014
Background Some 15 million people in England have a long-term condition (LTC) but there is concern about whether or not the NHS meets their needs. To address this, consecutive governments have developed policies aimed at improving service delivery and ...
Kendall, S., Williams, Lorraine, Wilson, Patricia M., Brooks, F., Peckham, S, Reay, J, Bloomfield, L., Fiona Brooks, Williams, L., Wilson, P, Peckham, Stephen, Kendall, S, Reay, Joanne, Stephen Peckham, Joanne Reay, Douglas Smallwood, Smallwood, Douglas, Sally Kendall, Smallwood, D, Lorraine Williams, Reay, J., Brooks, F, Smiddy, J., Linda Bloomfield, Brooks, Fiona, Smallwood, D., Kendall, Sally, Patricia Wilson, Jane Smiddy, Wilson, Patricia, Williams, L, Smiddy, J, Smiddy, Jane, Bloomfield, L, Bloomfield, Linda   +34 more
core   +1 more source

Effectiveness of legally mandated non-custodial drug and alcohol treatment orders for improved health, well-being, global functioning and quality of life: a systematic review and meta-analysis

Health & Justice
Background Adults in the criminal justice system are disproportionately more likely to use alcohol and drugs compared to the general population. Legally mandated alcohol and drug treatment orders have been proposed as an alternative to prison.
Pauline Campbell, Julie Cowie, Bridget Davis, Candida Fenton, Alex Todhunter-Brown, Hilda Bissozo Hernandez, Louise Hoyle, Hannah Carver, Catriona Connell, Joshua Dumbrell, Rosie Hill, Fiona Blacklaw, NIHR Evidence Synthesis Scotland InitiativE (NESSIE), Emma. F. France   +13 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

T022: Sharing decisions regarding radiotherapy for Hodgkin lymphoma: a qualitative study of the experiences of patients and clinicians in the UK

HemaSphere, 2022
Rebecca Shakir, Catriona Gilmour-Hamilton, Craig Bakin, Isabelle Gent, Adam Holloway, Alison Meeson, Johanna Ramroth, Georgios Ntentas, David Cutter, Michele Peters   +9 more
doaj   +1 more source