Results 81 to 90 of about 383,023 (311)

The Impact of Health Service Policy on Research and Development Activity in NHS Trust Research & Development Offices: A Survey of Research & Development Offices in England 2005/2006

, 2009
An electronically managed survey of NHS Research and Development (R & D) managers was conducted in 2005-2006 by the NHS RD Forum Service User and Carer Working Group.
Cooke, Mary, Minogue, Virginia, Minogue, V   +2 more
core   +1 more source

Patient and public involvement and engagement in a doctoral research project exploring self-harm in older adults [PDF]

, 2019
Background: The contribution of involving patients and public in health research is widely reported, particularly within mental health research. Less is written about such contributions to doctoral research.
Lisa Dikomitis, Adele Higginbottom, Opeyemi Babatunde, M. Isabela Troya, Carolyn A. Chew-Graham, Bernadette Bartlam   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Economic recession and long-term care. A scoping study [PDF]

, 2010
Despite its obvious appeal, the concept of public involvement is poorly defined and its rationale and objectives are rarely specified when applied to current health policy contexts.
Cacace, M, Goshev, S, Ettelt, S, Nolte, E   +3 more
core  

Understanding the role of patient and public involvement in renal dietetic research

, 2017
The objective was to consult patients on a proposed recruitment strategy to a patient and public involvement exercise. We wanted to explore the reasoning and willingness of patients to become co-researchers within a grant application.
Biggerstaff, Deborah, Krishnan, Nithya, Lycett, Deborah, Morris, Andrew, Mr   +3 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Valuing patient and public involvement in research

, 2014
Patient and public involvement is now mandatory in funding applications for most health sciences research.
Sutton, Emma, Maguire, Kath, Stevens, Shirley, Williams-Yesson, Barbara   +3 more
core  

Patient and public involvement in clinical guidelines: international experiences and future perspectives [PDF]

, 2010
Background Clinical practice guidelines (CPG) are important tools for improving patient care. Patient and public involvement is recognised as an essential component of CPG development and implementation, The Guideline International Network Patient and ...
van der Weijden, Trudy, Fervers, Beatrice, Marshall, Catherine, James, Marian, Sanger, Sylvia, Boivin, Antoine, Gracia, Javier, Grol, Richard P., Currie, Kay, Thomas, Victoria, Burgers, Jako S., Sakala, Carol, Strid, Judi, van der Weijden, Trudy; id_orcid   +13 more
core   +1 more source