Results 81 to 90 of about 411,635 (248)

“They are nae worrying about it… so …what’s the point in asking?”: A qualitative study of candidacy for early CKD care in areas of multiple deprivation

BMC Nephrology
Background Chronic kidney disease (CKD) is common, associated with substantial comorbidity and strong socioeconomic gradients. Early CKD care focuses on preventing disease progression and reducing cardiovascular risk. However, inequities in access to CKD
Buse Keskindag, Tom Blakeman, Audrey Hughes, Samira Bell, Mike Melvin, Fumiko Nakamaru, Melany Gray, Bhautesh Jani, Mhairi Mackenzie, Nicole Scholes-Robertson, Eilidh Cowan, Paul Cockwell, Simon Sawhney, Magdalena Rzewuska Diaz   +13 more
doaj   +1 more source

Overview of public and patient involvement in the study.

, 2023
Overview of public and patient involvement in the study.
Nicola O’Malley (11503615), Eileen O’Connor (17382772), Fiona McCullough Staunton (17382769), Susan Coote (6501500), Amanda M. Clifford (9580271)   +4 more
core   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Talking about living and dying with the oldest old: public involvement in a study on end of life care in care homes [PDF]

, 2011
Background: Public involvement in research on sensitive subjects, such as death and dying, can help to ensure that questions are framed to reflect the interests of their peers, develop a shared understanding of issues raised, and moderate the often ...
Mendoza Alex, Cowe Marion, Diane Munday, Katherine Froggatt, Munday Diane, Iliffe Steve, Wilson, Patricia M., Froggatt Katherine, Wilson Patricia M, Stephen Barclay, Gage, Heather, Heather Gage, Crang, Clare, Barclay Stephen, Elspeth Mathie, Patricia M Wilson, Clare Crang, Goodman Claire, Mathie, Elspeth, Barclay, Stephen, Daphne Westwood, Westwood Daphne, Alex Mendoza, Crang Clare, Froggatt, Katherine, Manthorpe Jill, Munday, Diane, Marion Cowe, Cowe, Marion, Iliffe, Steve, Jill Manthorpe, Mathie Elspeth, Goodman, Claire, Goodman, Claire M., Manthorpe, Jill; id_orcid, Wilson, Patricia, Westwood, Daphne, Gage Heather, Mendoza, Alex, Claire Goodman, Manthorpe, Jill, Steve Iliffe   +41 more
core   +4 more sources

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The patient-reported outcome measure for older people living with frailty receiving acute care (PROM-OPAC): field-testing and validation

Journal of Patient-Reported Outcomes
Background Current acute healthcare service metrics are not meaningful for older people living with frailty. Healthcare knowledge, situational security, and physical and psychosocial function are important outcomes typically not collected.
James D. van Oppen, Simon P. Conroy, Jagruti Lalseta, Nicola Mackintosh, Peter Riley, Vivien Richardson, Jose M. Valderas, Timothy J. Coats   +7 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

T022: Sharing decisions regarding radiotherapy for Hodgkin lymphoma: a qualitative study of the experiences of patients and clinicians in the UK

HemaSphere, 2022
Rebecca Shakir, Catriona Gilmour-Hamilton, Craig Bakin, Isabelle Gent, Adam Holloway, Alison Meeson, Johanna Ramroth, Georgios Ntentas, David Cutter, Michele Peters   +9 more
doaj   +1 more source