Results 101 to 110 of about 2,650,202 (337)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Promoting Strategies to Overcome Low Health Literacy and Improve Patient Understanding in Outpatient Setting [PDF]

open access: yes, 2016
Over 36% of US adults have low health literacy. This contributes to poorer health outcomes and increased costs for individuals and health care systems.
Siskind, Samantha M.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

A Layered Approach to Understanding Your Patient: A Tool for Patient Education

open access: yesMedEdPORTAL, 2013
Patient education encompasses more than just telling a patient to read materials; it is a process of working with a patient to promote behavioral change.
Jill Stefaniak
doaj   +1 more source

Foot and Ankle Patient Education Materials and Artificial Intelligence Chatbots: A Comparative Analysis [PDF]

open access: yesFoot Ankle Orthop
Background The purpose of this study was to perform a comparative analysis of foot and ankle patient education material generated by the AI chatbots, as they compare to the American Orthopaedic Foot and Ankle Society (AOFAS)-recommended patient education
Aarav S. Parekh   +5 more
europepmc   +2 more sources

One Size Does Not Fit All: Meeting the Health Care Needs of Diverse Populations [PDF]

open access: yes, 2008
Proposes a framework for meeting patients' cultural and linguistic needs: policies and procedures that support cultural competence, data collection, population-tailored services, and internal and external collaborations.
Amy Wilson-Stronks   +4 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

A Framework for Integrating Oncology Palliative Care in Doctor of Nursing Practice (DNP) Education [PDF]

open access: yes, 2018
Doctor of Nursing Practice (DNP) faculty play a critical role in preparing students to meet the complex needs of the nation as the number of cancer rates and survivors rise (National Cancer Institute, 2018) and as an unprecedented number of older ...
Breakwell, Susan   +4 more
core   +1 more source

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