Results 101 to 110 of about 4,410,602 (316)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

An observational study of the Patient-Centered Outcomes Research Institute’s switch from in-person to virtual research application review panels during the COVID-19 pandemic

Research Integrity and Peer Review
Background The Patient-Centered Outcomes Research Institute (PCORI) reviews research applications using a process that includes preliminary review by primary reviewers, followed by panel discussion where primary reviewers and other reviewers on the panel
Robin Bloodworth, Rachel Hemphill, Laura P. Forsythe, Carolyn Mohan, Esther C. Nolton, Ponta Abadi, Lisa J. Stewart, Krista P. Woodward   +7 more
doaj   +1 more source

Accelerating patient experience performance: Collaboration and engagement as drivers for success [PDF]

, 2017
The efforts at Albert Einstein Jewish Hospital in São Paulo, Brazil have been focused on principles of excellence for many years as realized in engagement in and commitment to some of the leading global healthcare practices over the last decade.
Klajner, Sidney, Sidney Klajner
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

From measures to meaning: a case study on co-defining aphasia recovery outcomes with patient experts

Research Involvement and Engagement
Background People with post-stroke aphasia are often excluded from shaping the research meant to support their recovery. Communication barriers, research norms, and traditional outcome frameworks contribute to a lack of meaningful involvement ...
Ann Blair Kennedy, Amy Neira, Katie Parris, Sebrena Brink, Patients With Aphasia Panel, Nabil Natafgi, Dirk B. Den Ouden, Sara Sayers, Leonardo Bonilha, Julius Fridriksson   +9 more
doaj   +1 more source

Engagement, empowerment and patient generated health data [PDF]

, 2017
This thesis examines patient generated health data in the context of healthcare services where information asymmetry traditionally enshrined the doctor as all-powerful and the patient as a passive recipient. Through vignette-led interviews and a clinical
Burns, Kara R.
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

“We’re all in this together”: patient and public involvement and engagement in developing a new psychosocial intervention for adults with an intellectual disability who display aggressive challenging behaviour

Research Involvement and Engagement
Background Although there is consensus regarding the added value of adults with an intellectual disability and family carers as Patient and Public Involvement and Engagement (PPIE) members in research studies, there is limited reporting on the practice ...
Connor Clarke, Athanasia Kouroupa, Rachel Royston, Angela Hassiotis, Yufei Jin, Vivien Cooper, Robert Daniels, Lisa Grimley, Sue Hay, Louise Marston, Olawole Odeyemi, Ian Penfold, Claire Pullar, Penny Rapaport, Kate Sanger, Adam Southworth, Laurence Taggart, Afia Ali   +17 more
doaj   +1 more source

The experiences of patients who leave hospital against medical advice: analysis of survey data

Frontiers in Health Services
BackgroundHistorically, when patients leave hospital against medical advice (LAMA), the focus has often been on non-compliance or other patient-level factors, rather than on how services may be designed to better support these patients. Efforts to better
Kyle Kemp, Kyle Kemp, Brian Steele, Paul Fairie, Maria Jose Santana, Maria Jose Santana, Maria Jose Santana   +6 more
doaj   +1 more source

A review and synthesis of frameworks for engagement in health research to identify concepts of knowledge user engagement

BMC Medical Research Methodology, 2019
Background Engaging those who influence, administer and/or who are active users (“knowledge users”) of health care systems, as co-producers of health research, can help to ensure that research products will better address real world needs. Our aim was to
Janet E. Jull, Laurie Davidson, Rachel Dungan, Tram Nguyen, Krista P. Woodward, Ian D. Graham   +5 more
doaj   +1 more source