Results 101 to 110 of about 4,662,895 (269)

Engaging rural residents in patient-centered health care research [PDF]

, 2017
Patient engagement is increasingly recognized as a critical component in improving health care. Yet, there remains a gap in our understanding of the intricacies of rural patient engagement in health-related research. This article describes the process of
Levy, Michelle, Whitney Grube, Amy Mendenhall, Michelle Levy, Mendenhall, Amy, Grube, Whitney, Holmes, Cheryl, Cheryl Holmes   +7 more
core   +1 more source

“We’re all in this together”: patient and public involvement and engagement in developing a new psychosocial intervention for adults with an intellectual disability who display aggressive challenging behaviour

Research Involvement and Engagement
Background Although there is consensus regarding the added value of adults with an intellectual disability and family carers as Patient and Public Involvement and Engagement (PPIE) members in research studies, there is limited reporting on the practice ...
Connor Clarke, Athanasia Kouroupa, Rachel Royston, Angela Hassiotis, Yufei Jin, Vivien Cooper, Robert Daniels, Lisa Grimley, Sue Hay, Louise Marston, Olawole Odeyemi, Ian Penfold, Claire Pullar, Penny Rapaport, Kate Sanger, Adam Southworth, Laurence Taggart, Afia Ali   +17 more
doaj   +1 more source

The experiences of patients who leave hospital against medical advice: analysis of survey data

Frontiers in Health Services
BackgroundHistorically, when patients leave hospital against medical advice (LAMA), the focus has often been on non-compliance or other patient-level factors, rather than on how services may be designed to better support these patients. Efforts to better
Kyle Kemp, Kyle Kemp, Brian Steele, Paul Fairie, Maria Jose Santana, Maria Jose Santana, Maria Jose Santana   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Evaluation of the Establishment of a Public and Patient Involvement and Engagement Group to Support Clinical Trials in Pakistan: Protocol for a Mixed-Methods Study [version 2; peer review: 2 approved]

Wellcome Open Research
Background Patient and public involvement and engagement (PPIE) in research is a collaboration between researchers, patients, and the public, enhancing research acceptability, relevance, and impact.
Monaza Khan, Shehla Farooq, Srinivas Murthy, Nikhat Ahmed, Saima Saleem, Adnan Masood, Shahnaz Zaman, Zahyd Shuja, Arishay Hussaini, Timo Tolppa, Arjen M Dondorp, Madiha Hashmi   +11 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Increasing patient engagement in healthcare service design: a qualitative evaluation of a co-design programme in New Zealand [PDF]

, 2017
The Health & Quality Safety Commission New Zealand commissioned Ko Awatea, an innovation and improvement centre, to deliver a co-design programme to nine teams of healthcare providers.
Brooke Hayward, Hayward, Patricia, Lynne Margaret Maher, Maher, Lynne Margaret, Dr., Hayward, Brooke, Walsh, Chris, Dr, Patricia Hayward, Lynne Maher, Chris Walsh   +8 more
core   +1 more source

A review and synthesis of frameworks for engagement in health research to identify concepts of knowledge user engagement

BMC Medical Research Methodology, 2019
Background Engaging those who influence, administer and/or who are active users (“knowledge users”) of health care systems, as co-producers of health research, can help to ensure that research products will better address real world needs. Our aim was to
Janet E. Jull, Laurie Davidson, Rachel Dungan, Tram Nguyen, Krista P. Woodward, Ian D. Graham   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Reframing the work on patient experience improvement [PDF]

, 2015
In reframing the work on patient experience improvement Dr. Jocelyn Cornwell, chief executive of The Point of Care Foundation, challenges us to broaden our view on what is necessary to impact patient experience efforts.
Jocelyn Cornwell, Cornwell, Jocelyn
core   +1 more source