Results 81 to 90 of about 4,410,602 (316)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Patient-Engagement - Die zukünftige Rolle des Nutzers in der Prothesenentwicklung

, 2020
Die Einbeziehung von Patientenerfahrung und -kompetenz während des gesamten Produktlebenszyklus' ist ein Schlüssel für überzeugende, patientenorientierte und innovative Produkte und Dienstleistungen. Patient Engagement wird auch unter regulatorischen und

core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Variation in parental experiences with their child’s hospitalization over the COVID-19 pandemic

Journal of Patient-Reported Outcomes, 2023
Background Hospitals and healthcare workers have been greatly impacted by the COVID-19 pandemic. The potential impacts upon the patient experience have been less documented, particularly in the pediatric setting.
Kyle A. Kemp, Paul Fairie, Brian Steele, Maria J. Santana   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Through Their Eyes: Using Photovoice to Capture the Capacity‐Building Journey of Long Covid Patient Experts

Health Expectations
Background Long Covid, characterised by persistent symptoms following the coronavirus disease 2019 (COVID‐19) infection, significantly impacts the quality of life.
Nabil Natafgi, Katie Parris, Erin Walker, Tracey Gartner, Jeanette Coffin, Ariana Mitcham, Luis Sanchez Ferrer, Maushmi K. Patel, Haley Wymbs, Ann Blair Kennedy   +9 more
doaj   +1 more source

Patient Engagement Partnerships in Clinical Trials: Development of Patient Partner and Investigator Decision Aids [PDF]

, 2020
Background: A 2017 systematic review suggested patient engagement in clinical trials has been limited, with little active engagement in trial design or data analysis, interpretation or dissemination.
Bjørnnes, Ann Kristin, Najam, Adhiyat, Ellis, Anne K, Parry, Monica, Toupin April, K, Marlin, Susan, Park, Marianne, Sivakumar, A, Gilron, Ian, Ceroni, Tina, Wells, David, Richards, Dawn   +11 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Patient Engagement and Co-creation in Healthcare Services: A Scoping Review [PDF]

Objective: The objective of this review was to find literature related to the concepts of patient engagement and co-creation in healthcare services and identify models and/or frameworks that combined these concepts.
Thiruppavai Sundaramurthi, Smita Mathews, Satish Mahajan, Ella Bermudez, Mathews, Smita, Mahajan, Satish M, Bermudez, Ella, Sundaramurthi, Thiruppavai   +7 more
core   +1 more source