Results 111 to 120 of about 4,662,895 (269)

Wonderings to research questions: Engaging patients in long COVID research prioritization within a learning health system

Learning Health Systems
Background An integral component of research within a learning health system is patient engagement at all stages of the research process. While there are well‐defined best practices for engaging with patients on predetermined research questions, there is
Ann Blair Kennedy, Ariana Mitcham, Katherine Parris, Faith Albertson, Luis Sanchez Ferrer, Conor O'Boyle, Maushmi K. Patel, Tracey Gartner, Amy M. Broomer, Evan Katzman, Jeanette Coffin, Jennifer T. Grier, Nabil Natafgi   +12 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Questioning patient engagement: research scientists’ perceptions of the challenges of patient engagement in a cardiovascular research network

, 2017
Sandra L Carroll,1 Gayathri Embuldeniya,1 Julia Abelson,2 Michael McGillion,1 Alexandre Berkesse,3 Jeff S Healey4 1Faculty of Health Sciences, School of Nursing, McMaster University, Hamilton, ON, 2Faculty of Health Sciences, Health Research Methods ...
McGillion M, Carroll SL, Abelson J, Healey JS, Embuldeniya G, Berkesse A   +5 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Enhancing System-Level Quality Improvement through Patient-Inclusive Teamwork: A Review

Engaging patients in quality improvement (QI) initiatives offers significant advantages, including increased patient satisfaction, improved outcomes, and the integration of creative insights from patient perspectives.
Mohiuddin, Shaik
core   +1 more source

Call for Submissions Special Issue - July 2020: Patient & Family Experience in Behavioral Health [PDF]

, 2019
Patient Experience Journal (PXJ) is excited to announce the call for submissions for its July 2020 special issue on the topic of patient & family experience in behavioral health. With a continued focus on the critical role of behavioral health in society
Journal, Patient Experience, Patient Experience Journal   +1 more
core   +1 more source

From patient to partner: Bridging the divide from laboratory to patient through a “Dragons' Den” style model of co-creation in cancer research

Technical Innovations & Patient Support in Radiation Oncology
Patient and public involvement and engagement (PPIE) in cancer research is increasingly recognised as valuable; yet meaningful participation early in the cancer research pathway remains less common, particularly in pre-clinical science [1] .
Ashwini Job, Beverly Agass, Charlotte E. Coles, Helene Judge, Andrew Land, Deborah Pitfield, Hilary Stobart, Amy Tang, Rhys Grant, Nicola Le Blond, Neil G. Burnet   +10 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Patient Engagement and Co-creation in Healthcare Services: A Scoping Review [PDF]

Objective: The objective of this review was to find literature related to the concepts of patient engagement and co-creation in healthcare services and identify models and/or frameworks that combined these concepts.
Thiruppavai Sundaramurthi, Smita Mathews, Satish Mahajan, Ella Bermudez, Mathews, Smita, Mahajan, Satish M, Bermudez, Ella, Sundaramurthi, Thiruppavai   +7 more
core   +1 more source