Results 91 to 100 of about 2,326,510 (303)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Applying Lean: Implementation of a Rapid Triage and Treatment System

Western Journal of Emergency Medicine, 2011
Objective: Emergency department (ED) crowding creates issues with patient satisfaction, long wait times and leaving the ED without being seen by a doctor (LWBS).
Murrell, Karen L, Offerman, Steven R, Kauffman, Mark B   +2 more
doaj  

Optimizing diagnostic and management pathways for patients with eosinophilia of unknown origin: a multidisciplinary protocol for urgent and non-urgent evaluation

Frontiers in Medicine
IntroductionPersistent eosinophilia of unknown cause is a key feature of numerous health disorders. These conditions present diagnostic and management challenges, often leading to delayed treatment, increased morbidity and mortality and unnecessary ...
Silvia Sánchez-Ramón, Gloria Candelas Rodríguez, Jesús Gimeno Hernández, María Luisa González Gutiérrez, Sissy Fiorella Medina Salazar, Manuel Méndez Bailón, Begoña Navas Elorza, Ángel Nieto Sánchez, Teresa Robledo Echarren, Santiago Rueda Esteban, Marcos Oliver Fragiel Saavedra, María Dolores Zamora Barrios, Cristina Martínez Prada, Celina Benavente Cuesta, Celia Pinedo Sierra, EOS Multidisciplinary Group   +15 more
doaj   +1 more source

Self-management support for chronic disease in primary care: frequency of patient self-management problems and patient reported priorities, and alignment with ultimate behavior goal selection. [PDF]

, 2019
BackgroundTo enable delivery of high quality patient-centered care, as well as to allow primary care health systems to allocate appropriate resources that align with patients' identified self-management problems (SM-Problems) and priorities (SM ...
Bowyer, Vicky, Dickinson, L Miriam, Dickinson, W Perry, Fernald, Douglas H, Fisher, Lawrence, Hessler, Danielle M, Jortberg, Bonnie T, Kwan, Bethany, Simpson, Matt   +8 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Pairwise agonist scanning-flow cytometry (PAS-FC) measures inside-out signaling and patient-specific response to combinatorial platelet agonists

BioTechniques, 2013
Understanding the response of cells to multiple stimuli is vital for predicting donor specific responses and better understanding the signaling pathways involved.
Daniel T. L. Jaeger, Scott L. Diamond
doaj   +1 more source

Stephen Klein Wellness Center Patient Satisfaction Survey: Development and Preliminary Results [PDF]

, 2016
Study design: •Selected the CAHPS® with Patient Centered Medical Home question set to administer to patients receiving medical care at SKWC (52 questions) •Included 2 supplemental questions to assess patients’ likelihood to refer others to SKWC ...
Brawer, MPH, PhD, Rickie, Flaxer, Joseph, Gilotra, MD, Mudit, Knudsen-Strong, MSc, Emily, Plumb, MD, MPH, James   +4 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An improved method of supercharged transposed latissimus dorsi flap with the skin paddle for the management of a complicated lumbosacral defect [PDF]

, 2015
OBJECTIVE: Treatment of nonhealing wounds of lower back often poses a powerful challenge. We present one of the first report of treatment of a lumbosacral defect with a supercharged latissimus dorsi flap with the skin paddle.
CIGNA, EMANUELE, CJ Salgado, H. C. Chen, I. Ponzo, O. Ozkan, P. Sassu, RIBUFFO, Diego, S. Mardini, SCUDERI, Nicolo', Y. T. Lieu   +9 more
core   +1 more source