Results 91 to 100 of about 7,769,754 (302)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Results Pending Unit: Improving Emergency Department Flow and Patient Satisfaction [paper]

open access: yes, 2019
Introduction: Overcrowding and boarding patients in the emergency departments (ED) leads to unacceptable patient care and staff productivity. When there is poor patient flow through the ED the following negative outcomes occur: increased patient wait ...
Hartman, Amy
core   +1 more source

Clinical handover within the emergency care pathway and the potential risks of clinical handover failure (ECHO): primary research

open access: yesHealth Services and Delivery Research, 2014
Background and objectives: Handover and communication failures are a recognised threat to patient safety. Handover in emergency care is a particularly vulnerable activity owing to the high-risk context and overcrowded conditions.
Mark Sujan   +8 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Flow-chart of patient inclusion and attrition in the study.

open access: yes
Flow-chart of patient inclusion and attrition in the study.
Jezabel Rivero Rodriguez (18509925)   +7 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Patient flow.

open access: yes, 2018
Patient flow.
Hans-Fritz Gramke (588052)   +7 more
core   +2 more sources

ENT Express : using patient journey modeling as an improvement tool for the Royal Newcastle ENT Ambulatory Care Clinics

open access: yes, 2011
Commencing in July 2010, the aim of ENT Express is to make recommendations that will ensure the Hunter New England Health Service (HNEAHS) provides a patient centered Ear, Nose and Throat ambulatory care service that meets the needs of the community ...
Curry, Joanne (R9655), McEwan, Todd
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

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